Ignite Creation Date:
2024-05-05 @ 4:42 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00295568
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-02-23
Brief Title:
Interaction of Right and Left Brain Hemispheres in Learning Precision Hand Movements
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Contribution of Interhemispheric Inhibition to Motor Learning
Status:
COMPLETED
Status Verified Date:
2009-01-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine how the two sides of the brain interact when learning precision hand movements Both sides of the brain are active when a person performs an accurate hand movement This study will look at the extent to which the two brain hemispheres interact when learning accurate hand movements
Healthy right-handed normal volunteers 18 - 40 years of age may be eligible for this study Candidates are screened with a clinical and neurological examination
Participants are randomly assigned to one of two groups - precision or non-precision hand movements All participants undergo the following procedures
Force precision task Subjects are press a small device between the thumb and index finger The force produced with the fingertips is translated onto a computer screen Subjects track a white line passing on the screen with their fingertips
Paired-pulse transcranial magnetic stimulation TMS A wire coil is held to the subjects scalp A brief electrical current is passed through the coil creating a magnetic pulse that stimulates the brain During the stimulation the subject may be asked to tense certain muscles slightly or perform other simple actions The stimulation may cause a twitch in muscles of the face arm or leg and the subject may hear a click and feel a pulling sensation on the skin under the coil The effect of paired-pulse TMS on the muscles is detected with electrodes taped to the skin on the arms or legs
Surface electromyography EMG This test measures the electrical activity of muscles For this test electrodes are filled with a gel and taped to the skin over the muscle to be tested
The study involves six sessions Sessions 1-5 are on consecutive days session 6 is one week after session 5
Session 1 Familiarization with the motor task and baseline measurements including error rate EMG and paired-pulse TMS
Session 2 Training in the motor task and repeat measurements as in session 1
Session 3 Training and measurements as in session 2
Session 4 Training and measurements as in session 2
Session 5 Training and measurements as in session 2
Session 6 Measurements only
Healthy right-handed normal volunteers 18 - 40 years of age may be eligible for this study Candidates are screened with a clinical and neurological examination
Participants are randomly assigned to one of two groups - precision or non-precision hand movements All participants undergo the following procedures
Force precision task Subjects are press a small device between the thumb and index finger The force produced with the fingertips is translated onto a computer screen Subjects track a white line passing on the screen with their fingertips
Paired-pulse transcranial magnetic stimulation TMS A wire coil is held to the subjects scalp A brief electrical current is passed through the coil creating a magnetic pulse that stimulates the brain During the stimulation the subject may be asked to tense certain muscles slightly or perform other simple actions The stimulation may cause a twitch in muscles of the face arm or leg and the subject may hear a click and feel a pulling sensation on the skin under the coil The effect of paired-pulse TMS on the muscles is detected with electrodes taped to the skin on the arms or legs
Surface electromyography EMG This test measures the electrical activity of muscles For this test electrodes are filled with a gel and taped to the skin over the muscle to be tested
The study involves six sessions Sessions 1-5 are on consecutive days session 6 is one week after session 5
Session 1 Familiarization with the motor task and baseline measurements including error rate EMG and paired-pulse TMS
Session 2 Training in the motor task and repeat measurements as in session 1
Session 3 Training and measurements as in session 2
Session 4 Training and measurements as in session 2
Session 5 Training and measurements as in session 2
Session 6 Measurements only
Detailed Description:
The purpose of this protocol is to investigate the changes in interhemispheric inhibition IHI between human motor cortices with learning of performance of an accurate motor task pinch force control Performing a simple motor task is associated with activation in the contralateral motor areas Activation of the ipsilateral motorpremotor cortex might be elicited by performing more challenging and difficult unimanual motor tasks However the functional role played by this ipsilateral activation has been controversial and is felt to be more prominent with more complex tasks Several studies using paired-pulse transcranial magnetic stimulation TMS revealed a significant IHI from the active upon the non-active hemisphere Together these results suggested IHI between motor cortical areas may play a critical role in motor control and could influence manual dexterity Taking these into account it raises the interesting question of whether the IHI balance between both motor cortices is progressively modified during the learning phase of an accurate motor task We hypothesize that learning to perform a tracking motor task requiring accurate control of pinch force generation Tracking accurate will increase IHI from the learning to the non-learning hemisphere to a larger extent than learning to perform a less precise tracking motor task Tracking non-accurate The primary outcome measure will be the amount of changes in IHI from the learning to the non-learning hemisphere as a function of learning both motor tasks
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 06-N-0095 | None | None | None |