Ignite Creation Date:
2024-05-05 @ 4:41 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00298909
Status:
COMPLETED
Last Update Posted:
2012-07-31
First Post:
2006-03-02
Brief Title:
Exercise Versus Niacin in Patients With Coronary Artery Disease CAD and Low High-Density Lipoproteins HDL
Sponsor:
University of Leipzig
Organization:
University of Leipzig
Study Overview
Official Title:
Exercise Versus Extended-Release Niacin in Patients With Coronary Heart Disease and Low High-Density Lipoproteins HDL Cholesterol Effect on Lipid Profile and Endothelial Function
Status:
COMPLETED
Status Verified Date:
2012-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators want to study the relative effects of physical exercise vs extended-release niacin lipid-lowering drug in patients with coronary heart disease and low HDL cholesterol good cholesterol on
lipid profile
endothelial function as measured by ultrasound
The endothelium is the inner part of the blood vessels Impaired endothelial function is known to be associated with atherosclerosis which can ultimately lead to diseases such as stroke heart attack and others Endothelial function can be assessed non-invasively by ultrasound
Both interventions mentioned above have been shown to have a beneficial effect on lipid profile and endothelial function However the relative effects are unclear
lipid profile
endothelial function as measured by ultrasound
The endothelium is the inner part of the blood vessels Impaired endothelial function is known to be associated with atherosclerosis which can ultimately lead to diseases such as stroke heart attack and others Endothelial function can be assessed non-invasively by ultrasound
Both interventions mentioned above have been shown to have a beneficial effect on lipid profile and endothelial function However the relative effects are unclear
Detailed Description:
Comparison of physical exercise vs extended-release niacin in patients with CAD and low HDL cholesterol 103 mmolL on lipid profile and endothelial function as measured by flow-mediated dilatation of radial artery Secondary goals are the assessment of biochemical markers of atherosclerosis expression of monocyte surface markers oxidative stress and thrombogenicity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None