Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001226
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Lipoprotein Metabolism in Normal Volunteers and Patients With Abnormal Levels of Lipoproteins
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Lipoprotein Metabolism in Normal Volunteers and Dyslipoproteinemic Patients Stable Isotopes
Status:
COMPLETED
Status Verified Date:
2002-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Researchers plan to study the fat-rich particles called lipoproteins which circulate in the blood This study is designed to improve understanding of normal as well as abnormal lipoprotein metabolism and the role it plays in the development of hardening of the arteries atherosclerosis
Patients participating in this study will receive an intravenous directly into the vein injection of a small amount of specially prepared amino acids The amino acids being injected are the same amino acids present in a normal diet The amount of amino acid given will be less than the amount eaten in a protein-rich meal The amino acids will be labeled with nonradioactive heavy isotopes which are also present in the environment n low amounts
Patients participating in the study will be required to have blood samples taken and provide urine samples throughout the course of the study In addition patient will be required to follow a specially formulated diet Patients will be weighed throughout the course of the study
Patients participating in this study will receive an intravenous directly into the vein injection of a small amount of specially prepared amino acids The amino acids being injected are the same amino acids present in a normal diet The amount of amino acid given will be less than the amount eaten in a protein-rich meal The amino acids will be labeled with nonradioactive heavy isotopes which are also present in the environment n low amounts
Patients participating in the study will be required to have blood samples taken and provide urine samples throughout the course of the study In addition patient will be required to follow a specially formulated diet Patients will be weighed throughout the course of the study
Detailed Description:
Apolipoproteins regulate the metabolism of lipids and lipoproteins in plasma of humans In order to investigate the roles of apolipoproteins in these processes we plan to quantitate the kinetics of the metabolism of apolipoproteins utilizing nonradioactive isotope labeled amino-acids
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 87-H-0207 | None | None | None |