Ignite Creation Date:
2024-05-06 @ 11:03 AM
Last Modification Date:
2024-10-26 @ 12:39 PM
Study NCT ID:
NCT03421444
Status:
COMPLETED
Last Update Posted:
2018-02-05
First Post:
2018-01-09
Brief Title:
Beijing Children and Adolescents Metabolic Syndrome Study BCAMS Study
Sponsor:
Peking Union Medical College Hospital
Organization:
Peking Union Medical College Hospital
Study Overview
Official Title:
Beijing Children and Adolescents Metabolic Syndrome Study BCAMS Study
Status:
COMPLETED
Status Verified Date:
2018-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BCAMS
Brief Summary:
Base on enriched resources from the Metabolic Syndrome cohort in children a long-term prospective cohort study will be carried out This cohort is a unique biochemical and genetic database of Chinese population with large number of subjects in the world By collecting information of disease history and lifestyle measuring clinical and metabolic parameters especially biomarkers which can reflect the underlying mechanism of insulin resistance and metabolic syndrome we intend to sort out some unique biochemical and genetic markers for Chinese population
Detailed Description:
A representative sample of 19593 school children aged 6-18 years were chosen from four of the eight urban districts and three of seven rural districts in the Beijing area between April and October 2004 Among these children and adolescents 4500 were recognized as having risk factors defined by the presence of any one of the following overweight total cholesterol TC 52 mmolL triglyceride TG 17 mmolL or fasting glucose FG 56 mmolL based on initial finger capillary blood tests Moreover all subjects at increased risk for metabolic syndrome together with a parallel reference population of 1095 children were invited to undergo medical examinations for verification based on venipuncture blood samples Clinical data biomarkers including adipokines and lifestyle factors such as physical activity and diet were measured and documented Genetic variants previously reported from genome-wide association study GWAS of obesity and diabetes and DNA-methylation were also assessed Further high-throughput analysis of proteomics and metabolomics of the blood samples were conducted Cross-sectional and follow-up evaluations will be undertaken The unique biochemical and genetic markers for Chinese population will be identified in the BCAMS study The biomarkers will build a solid foundation for progressive study on mechanism of metabolic diseases and lead to early prediction of these diseases
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None