Ignite Creation Date:
2024-05-05 @ 4:40 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00296296
Status:
COMPLETED
Last Update Posted:
2017-10-06
First Post:
2006-02-22
Brief Title:
Immunosuppression Impact on the Metabolic Control of Kidney Transplant With Pre-Existing Type 2 Diabetes DM
Sponsor:
Stanford University
Organization:
Stanford University
Study Overview
Official Title:
Randomized Open Label Study Comparing the Metabolic Control of Kidney Transplant Recipients With Type 2 Diabetes Receiving Either Prograf or Neoral as Part of a ATG Induction Prednisone Free and Monitored MMF Immunosuppressive Regimen
Status:
COMPLETED
Status Verified Date:
2017-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Protocol Title Randomized open label study comparing the metabolic control of first Kidney Transplant recipients with Type 2 Diabetes Mellitus DM receiving either Prograf or Neoral as part of a ATG induction prednisone free and blood monitored Cellcept immunosuppressive regimen
PURPOSE This is a single center medical research study to analyze post-transplant kidney recipients with pre-existing type 2 diabetes managed according to the recommended American Diabetes Association ADA guidelines Prograf Tac and Neoral CSA are the two main medications to prevent rejection after transplantation However they may contribute to poorer diabetes control The purpose of the study is to compare the effects of Prograf and Neoral on the control of Diabetes after kidney transplantation In addition all participants in this study will receive Thymoglobulin anti-lymphocyte globulin at the time of transplantation instead of long term prednisone steroids
PURPOSE This is a single center medical research study to analyze post-transplant kidney recipients with pre-existing type 2 diabetes managed according to the recommended American Diabetes Association ADA guidelines Prograf Tac and Neoral CSA are the two main medications to prevent rejection after transplantation However they may contribute to poorer diabetes control The purpose of the study is to compare the effects of Prograf and Neoral on the control of Diabetes after kidney transplantation In addition all participants in this study will receive Thymoglobulin anti-lymphocyte globulin at the time of transplantation instead of long term prednisone steroids
Detailed Description:
It has been accepted that patients with DM are associated with a greater risk of morbidity and mortality and hyperlipidemia compromised graft function stroke nephropathy atherosclerotic cardiovascular disease graft-loss infection retinopathy neuropathy gastropathy and vascular complications2
Patients with pre-existing DM had a 19 times less survival days3 In renal transplantation twice as many patients with pre-existing diabetes die with functioning graft4
DM has been shown to be predominantly the single most important predictor for adverse outcomes in terms of mortality and morbidity resulting from various end organ damages
Poor DM control leads to an increased risk of both graft loss and patient death due to manifestations of end-stage DM8 Chronic Allograft Nephritis CAN is a common finding at the 6th month post kidney transplant especially in patients with blood glucose metabolism abnormalities
Several conditions may lead the worsening of the diabetes after transplantation First for patients with ESRD the improvement of kidney function after kidney transplantation leads also to an increased clearance of circulating insulin Second most patients experience a significant improvement of well being after successful transplantation Often their appetite is significantly improved resulting in a significant weight gain - increasing insulin demand and resistance Finally most immunosuppressive medications are diabetogenic Corticoid-steroids are well known for their strong diabetogenic effect and have been associated with post transplant diabetes Calcineurin inhibitors are now the corner stone of immunosuppression for organ transplantation This class of medication includes cyclosporine and tacrolimus Both have been associated with post transplantation diabetes Induction agents including polyclonal antibodies ex Thymoglobulin and monoclonal antibodies ex Anti Il-2 receptor Zenapax Simulect are not found to cause hyperglycaemia The two areas of possible intervention to minimize worse diabetes after transplantation are thus limited to 1 comprehensive diabetes education and 2 newer immunosuppressive regimen after transplantation
11 Comprehensive Diabetes Education
DM can arise both in the stressful time of organ failure or in the post-transplant phase During a prospective study we conducted on solid organ transplant recipients with pre-existing and post transplant diabetes we observed the following trends
The complex nature of organ transplantation carries potential side effects which are amenable to early intervention in the post transplant setting with patients who have diabetes through education and monitoring by the transplant team
Patients with poorly controlled diabetes post transplant have a higher incidence of post transplant morbidity
Our study showed a 7 DM-related re-admissions within one year post-transplant for patients in the Diabetes and Transplant Program compared to a 93 DM-related re-admission rate within one year for patients not enrolled in the Program10
Further analysis of Stanford Medical Centers Transplant Diabetes Program revealed that patients average HbA1c was 88 at intake into the program Patients who were followed by this multi disciplinary Transplant Diabetes education team resulted in an average value of 72 following a minimum of three months of management 11
12 Immunosuppression for Transplant Patients with Diabetes The utilization of a calcineurin inhibitor in combination with steroids has contributed to the improved success of transplantation seen since the introduction of cyclosporine in 1983 Prograf also a calcineurin inhibitor was introduce later 1989 and was associated with further improvement in results Newer immunosuppressive medication has been introduced since then There has been interest in the transplant community to use the new agents to achieve steroid minimization or avoidance These strategies are very appealing for the diabetic patients as both steroids and calcineurin inhibitors are the most diabetogenic medication they receive after transplantation
121 STEROIDS Stanfords Pediatric kidney transplant team have demonstrated the feasibility of steroid avoidance or rapid taper after kidney transplantation Doctor Salvatierra team substituted Zenapax induction therapy for steroids in a series of pediatric kidney transplant recipients Patients received as well tacrolimus and MMF for prophylaxis of rejection They initially reported their experience with the first 34 patients 5-21 years old treated with that protocol The graft survival was 100 and the incidence of acute rejection was rejection 6 compared with 15 for historical controls receiving steroids They had no post transplantation diabetes or high blood pressure cholesterol was lower obesity and appearance was also significantly better12 Steroid avoidance is now the standard treatment for Stanfords Pediatric Transplant Program
The adult Kidney Transplant Program has been able to reproduce the pediatric experience with a similarly designed steroid avoidance protocol A slightly different approach has also been successfully used Kidney transplant recipients received Thymoglobulin induction in lieu of Zenapax and received 4 small doses of steroids peri-operatively So far 25 patients were treated with this minimal exposure to steroids The graft and patient survival is 100 and only one episode of rejection was seen This approach is preferred to the total avoidance of steroids since it is associated with a better initial kidney function13 This later approach is currently used by Stanfords Adult Kidney Transplant Program for un-sensitized adult patients receiving a kidney transplant if they have a medical condition that could be exacerbated by the use of steroids diabetes obesity osteopenia and coronary artery disease
Utilisation of Thymoglobulin was associated with a lower incidence of acute rejection than IL-2RA Xiao et Al showed the absence of Post Transplant Diabetes Mellitus PTDM and decreased use of anti-hypertensive medication in the steroid free group
Minimization of steroid use has clear metabolic benefits for the diabetic patients Within Stanford University Transplant service there is enough experience to support its safe use In this study all patients will have minimal exposure to steroids We have opted to give only peri-operative steroids 4 doses total as in our experience this approach is associated with better initial graft function than the complete steroid avoidance We also elected to use induction therapy with Thymoglobulin as it is associated with the lowest rate of rejection rate in the above mentioned studies14
122 Calcineurin inhibitors Calcineurin inhibitors have also been associated with post transplant diabetes The incidence of PTDM has been reported to be more than 30 depending on the calcineurin inhibitor used Cyclosporine vs Prograf trough level race and risk factors for diabetes all contribute to this number These figures may underestimate the true incidence of PTDM as most studies have not utilized the strict criteria of the ADA for diagnosis of diabetes Most studies report a higher incidence of PTDM with the use of Prograf compared to Cyclosporine The greater diabetogenicity of Prograf has been confirmed in a recent study investigating the new onset of diabetes both before and after kidney transplant14 this study revealed that the incidence of new-onset diabetes was 70 higher in Prograf treated patients than with patients receiving Neoral16 This contrasts with studies mentioned above where Prograf is used in steroid free protocols with no or very low incidence of post transplant diabetes
Calcineurin inhibitors do remain the corner stone of immunosuppression at the present time and even more so in the context of steroid minimization It would thus be very important to determine if one of the two calcineurin inhibitors available on the market has a more favourable metabolic profile specifically for patients with pre-existing diabetes Direct comparison between Neoral micro-emulsion formulation of CSA and Prograf has never been made in context of short steroid taper and specifically for non-insulin dependent diabetic patients
Equitable comparison between Neoral and Prograf is difficult as both drugs do not have the same pharmacokinetic profile Trough or pre-dose level has been used to evaluate drug exposure and make dosage adjustment Prograf has a more predictive correlation between the trough level and the total area under the curve total drug exposure of the patient than Neoral C2 monitoring of CSA consists of measuring the drug level 2 hours after ingestion The correlation of C2 monitoring of Neoral to the area under the curve is similar to the correlation of the trough for Prograf to the area under the curve both R 2092 C2 monitoring for Neoral has been associated with an increase in efficacy and reduction in toxicity In this study we will use C2 monitoring for Neoral and trough monitoring for Prograf Moderate minimization of the calcineurin inhibitor dosage will be used in this study in order to reduce the deleterious effect of the calcineurin inhibitors to the metabolism of glucose A reduction of approximately 20 of our usual target level will be used
123 Cellcept MMF Utilization of MMF is combination of Prograf or Neoral is the standard treatment after kidney transplantation Mycophenolic acid MPA is the active component of MMF Therapeutic drug monitoring of MPA has been shown to reduce rejection and toxicity15 Furthermore cyclosporine interferes with MPA metabolism resulting in a lower exposure to the drug compared to patients receiving Prograf when a fix dose is used MPA monitoring may thus ensure that patients in our study are within therapeutic window of this immunosuppressive agent This may prove to be even more crucial as they are not receiving steroids MPA monitoring will also ensure that Neoral and Prograf groups receive the similar drug exposure to MPA
124 Conclusion
Patients with diabetes are at higher risks of morbidity and mortality after kidney transplantation Currently there is no published data on the morbidity and mortality of these high risk patients from a prospective study that utilizes the American Diabetes Association ADA criteria for diabetes management and control nor which addresses
The impact of steroids elimination on outcomes after kidney transplantation and metabolic control in patients with pre-existing type 2 diabetes
Optimization of CI therapy for post transplant patients with pre-existing type 2 DM and its impact on metabolic control
The proposed study compares the effect of Calcineurin inhibitors have on metabolic control in the absence of corticosteroids to better optimize post-transplant patient outcomes and decrease morbidity in patients with DM With close monitoring of transplant recipient immunosuppression protocol elimination of CS and the reduction of CI therapy we propose there will be a decrease in patient morbidity associated with DM
The findings of this study may help
Identify optimal immunosuppression therapy for transplant patients with diabetes
Decrease DM related co-morbidities and hospital readmissions
Increase longevity of life and graft survival in transplant recipients with DM
Lower overall post-transplant health care costs that are attributed to the morbidity of immunosuppression therapy and diabetes
Promote better DM self-care in the transplant process
Results from this study where 100 of the studied population is diabetic may provide further insight in the metabolism of glucose after transplantation resulting in better understanding of post transplant diabetes
During the conduct of the study the outcomes were amended to included freedom from insulin therapy estimated glomerular filtration rate eGFR as an indicator of graft function post-operative survival up to 1 year and biopsy-proven transplant rejection
Patients with pre-existing DM had a 19 times less survival days3 In renal transplantation twice as many patients with pre-existing diabetes die with functioning graft4
DM has been shown to be predominantly the single most important predictor for adverse outcomes in terms of mortality and morbidity resulting from various end organ damages
Poor DM control leads to an increased risk of both graft loss and patient death due to manifestations of end-stage DM8 Chronic Allograft Nephritis CAN is a common finding at the 6th month post kidney transplant especially in patients with blood glucose metabolism abnormalities
Several conditions may lead the worsening of the diabetes after transplantation First for patients with ESRD the improvement of kidney function after kidney transplantation leads also to an increased clearance of circulating insulin Second most patients experience a significant improvement of well being after successful transplantation Often their appetite is significantly improved resulting in a significant weight gain - increasing insulin demand and resistance Finally most immunosuppressive medications are diabetogenic Corticoid-steroids are well known for their strong diabetogenic effect and have been associated with post transplant diabetes Calcineurin inhibitors are now the corner stone of immunosuppression for organ transplantation This class of medication includes cyclosporine and tacrolimus Both have been associated with post transplantation diabetes Induction agents including polyclonal antibodies ex Thymoglobulin and monoclonal antibodies ex Anti Il-2 receptor Zenapax Simulect are not found to cause hyperglycaemia The two areas of possible intervention to minimize worse diabetes after transplantation are thus limited to 1 comprehensive diabetes education and 2 newer immunosuppressive regimen after transplantation
11 Comprehensive Diabetes Education
DM can arise both in the stressful time of organ failure or in the post-transplant phase During a prospective study we conducted on solid organ transplant recipients with pre-existing and post transplant diabetes we observed the following trends
The complex nature of organ transplantation carries potential side effects which are amenable to early intervention in the post transplant setting with patients who have diabetes through education and monitoring by the transplant team
Patients with poorly controlled diabetes post transplant have a higher incidence of post transplant morbidity
Our study showed a 7 DM-related re-admissions within one year post-transplant for patients in the Diabetes and Transplant Program compared to a 93 DM-related re-admission rate within one year for patients not enrolled in the Program10
Further analysis of Stanford Medical Centers Transplant Diabetes Program revealed that patients average HbA1c was 88 at intake into the program Patients who were followed by this multi disciplinary Transplant Diabetes education team resulted in an average value of 72 following a minimum of three months of management 11
12 Immunosuppression for Transplant Patients with Diabetes The utilization of a calcineurin inhibitor in combination with steroids has contributed to the improved success of transplantation seen since the introduction of cyclosporine in 1983 Prograf also a calcineurin inhibitor was introduce later 1989 and was associated with further improvement in results Newer immunosuppressive medication has been introduced since then There has been interest in the transplant community to use the new agents to achieve steroid minimization or avoidance These strategies are very appealing for the diabetic patients as both steroids and calcineurin inhibitors are the most diabetogenic medication they receive after transplantation
121 STEROIDS Stanfords Pediatric kidney transplant team have demonstrated the feasibility of steroid avoidance or rapid taper after kidney transplantation Doctor Salvatierra team substituted Zenapax induction therapy for steroids in a series of pediatric kidney transplant recipients Patients received as well tacrolimus and MMF for prophylaxis of rejection They initially reported their experience with the first 34 patients 5-21 years old treated with that protocol The graft survival was 100 and the incidence of acute rejection was rejection 6 compared with 15 for historical controls receiving steroids They had no post transplantation diabetes or high blood pressure cholesterol was lower obesity and appearance was also significantly better12 Steroid avoidance is now the standard treatment for Stanfords Pediatric Transplant Program
The adult Kidney Transplant Program has been able to reproduce the pediatric experience with a similarly designed steroid avoidance protocol A slightly different approach has also been successfully used Kidney transplant recipients received Thymoglobulin induction in lieu of Zenapax and received 4 small doses of steroids peri-operatively So far 25 patients were treated with this minimal exposure to steroids The graft and patient survival is 100 and only one episode of rejection was seen This approach is preferred to the total avoidance of steroids since it is associated with a better initial kidney function13 This later approach is currently used by Stanfords Adult Kidney Transplant Program for un-sensitized adult patients receiving a kidney transplant if they have a medical condition that could be exacerbated by the use of steroids diabetes obesity osteopenia and coronary artery disease
Utilisation of Thymoglobulin was associated with a lower incidence of acute rejection than IL-2RA Xiao et Al showed the absence of Post Transplant Diabetes Mellitus PTDM and decreased use of anti-hypertensive medication in the steroid free group
Minimization of steroid use has clear metabolic benefits for the diabetic patients Within Stanford University Transplant service there is enough experience to support its safe use In this study all patients will have minimal exposure to steroids We have opted to give only peri-operative steroids 4 doses total as in our experience this approach is associated with better initial graft function than the complete steroid avoidance We also elected to use induction therapy with Thymoglobulin as it is associated with the lowest rate of rejection rate in the above mentioned studies14
122 Calcineurin inhibitors Calcineurin inhibitors have also been associated with post transplant diabetes The incidence of PTDM has been reported to be more than 30 depending on the calcineurin inhibitor used Cyclosporine vs Prograf trough level race and risk factors for diabetes all contribute to this number These figures may underestimate the true incidence of PTDM as most studies have not utilized the strict criteria of the ADA for diagnosis of diabetes Most studies report a higher incidence of PTDM with the use of Prograf compared to Cyclosporine The greater diabetogenicity of Prograf has been confirmed in a recent study investigating the new onset of diabetes both before and after kidney transplant14 this study revealed that the incidence of new-onset diabetes was 70 higher in Prograf treated patients than with patients receiving Neoral16 This contrasts with studies mentioned above where Prograf is used in steroid free protocols with no or very low incidence of post transplant diabetes
Calcineurin inhibitors do remain the corner stone of immunosuppression at the present time and even more so in the context of steroid minimization It would thus be very important to determine if one of the two calcineurin inhibitors available on the market has a more favourable metabolic profile specifically for patients with pre-existing diabetes Direct comparison between Neoral micro-emulsion formulation of CSA and Prograf has never been made in context of short steroid taper and specifically for non-insulin dependent diabetic patients
Equitable comparison between Neoral and Prograf is difficult as both drugs do not have the same pharmacokinetic profile Trough or pre-dose level has been used to evaluate drug exposure and make dosage adjustment Prograf has a more predictive correlation between the trough level and the total area under the curve total drug exposure of the patient than Neoral C2 monitoring of CSA consists of measuring the drug level 2 hours after ingestion The correlation of C2 monitoring of Neoral to the area under the curve is similar to the correlation of the trough for Prograf to the area under the curve both R 2092 C2 monitoring for Neoral has been associated with an increase in efficacy and reduction in toxicity In this study we will use C2 monitoring for Neoral and trough monitoring for Prograf Moderate minimization of the calcineurin inhibitor dosage will be used in this study in order to reduce the deleterious effect of the calcineurin inhibitors to the metabolism of glucose A reduction of approximately 20 of our usual target level will be used
123 Cellcept MMF Utilization of MMF is combination of Prograf or Neoral is the standard treatment after kidney transplantation Mycophenolic acid MPA is the active component of MMF Therapeutic drug monitoring of MPA has been shown to reduce rejection and toxicity15 Furthermore cyclosporine interferes with MPA metabolism resulting in a lower exposure to the drug compared to patients receiving Prograf when a fix dose is used MPA monitoring may thus ensure that patients in our study are within therapeutic window of this immunosuppressive agent This may prove to be even more crucial as they are not receiving steroids MPA monitoring will also ensure that Neoral and Prograf groups receive the similar drug exposure to MPA
124 Conclusion
Patients with diabetes are at higher risks of morbidity and mortality after kidney transplantation Currently there is no published data on the morbidity and mortality of these high risk patients from a prospective study that utilizes the American Diabetes Association ADA criteria for diabetes management and control nor which addresses
The impact of steroids elimination on outcomes after kidney transplantation and metabolic control in patients with pre-existing type 2 diabetes
Optimization of CI therapy for post transplant patients with pre-existing type 2 DM and its impact on metabolic control
The proposed study compares the effect of Calcineurin inhibitors have on metabolic control in the absence of corticosteroids to better optimize post-transplant patient outcomes and decrease morbidity in patients with DM With close monitoring of transplant recipient immunosuppression protocol elimination of CS and the reduction of CI therapy we propose there will be a decrease in patient morbidity associated with DM
The findings of this study may help
Identify optimal immunosuppression therapy for transplant patients with diabetes
Decrease DM related co-morbidities and hospital readmissions
Increase longevity of life and graft survival in transplant recipients with DM
Lower overall post-transplant health care costs that are attributed to the morbidity of immunosuppression therapy and diabetes
Promote better DM self-care in the transplant process
Results from this study where 100 of the studied population is diabetic may provide further insight in the metabolism of glucose after transplantation resulting in better understanding of post transplant diabetes
During the conduct of the study the outcomes were amended to included freedom from insulin therapy estimated glomerular filtration rate eGFR as an indicator of graft function post-operative survival up to 1 year and biopsy-proven transplant rejection
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None