Ignite Creation Date:
2024-05-06 @ 11:01 AM
Last Modification Date:
2024-10-26 @ 12:39 PM
Study NCT ID:
NCT03413046
Status:
UNKNOWN
Last Update Posted:
2018-01-29
First Post:
2017-12-21
Brief Title:
The Effect of Chemotherapy on Regulatory T Cells
Sponsor:
Ankara Childrens Health and Diseases Hematology and Oncology Training and Research Hospital
Organization:
Ankara Childrens Health and Diseases Hematology and Oncology Training and Research Hospital
Study Overview
Official Title:
The Effect of Chemotherapy on Regulatory T Cells in Children With Acute Lymphoblastic Leukemia
Status:
UNKNOWN
Status Verified Date:
2018-01
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators aimed to study the effect of chemotherapy on regulatory T cells Tregs in children with precursor B PreB acute lymphoblastic leukemia ALL at 15 and 33 days of malignity directed therapy The investigators will analyze peripheral and bone marrow blood samples of the participants obtained at diagnosis 15 and 33 days of treatment about Treg non Treg cells and interleukin IL-2 IL-6 IL-10 and transforming growth factor TGF beta levels By this means investigators will search response to chemotherapy Also investigators will analyze correlation between Treg population-Treg related cytokines with demographic clinical and laboratory findings of the participants with ALL at these certain time points Additionally the investigators will compare Treg population and minimal residual disease at 15-33 days of malignity directed therapy Also investigators will compare these Treg-Treg related cytokines obtained from the participants with ALL and a healthy children control group whom are voluntary donors for bone marrow transplantation
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None