Ignite Creation Date:
2024-05-06 @ 11:01 AM
Last Modification Date:
2024-10-26 @ 12:39 PM
Study NCT ID:
NCT03417063
Status:
UNKNOWN
Last Update Posted:
2018-01-31
First Post:
2018-01-24
Brief Title:
Intracranial Artery Stenosis Magnetic Resonance Imaging Aetiology and Progression
Sponsor:
Tsinghua University
Organization:
Tsinghua University
Study Overview
Official Title:
Intracranial Artery Stenosis Magnetic Resonance Imaging Aetiology and Progression ICASMAP
Status:
UNKNOWN
Status Verified Date:
2018-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Stroke has become the leading cause of death in China It has been shown that intracranial artery stenosis ICAS plays a key role in Chinese stroke patients Although most of stenotic diseases in intracranial arteries are atherosclerotic a substantial number of other vascular diseases such as dissection arteritis moyamoya disease and reversible cerebral vasoconstriction syndrome RCVS can also lead to intracranial artery luminal narrowing It is challenging to differentiate the etiologies of ICAS relying on measuring luminal narrowing by angiographical approaches In addition the progression of intracranial atherosclerotic disease ICAD has been demonstrated to be highly associated with the risk of ischemic cerebrovascular events However the influence factors for ICAD progression remains unclear
High-resolution magnetic resonance imaging HR-MRI has been widely used to assess ICAS diseases The different etiologies of ICAS are differentiable by MR-MRI according to the features of location shape signal pattern remodeling and contrast enhancement Investigators have proved that HR-MRI is a reproducible technique that may be reliably utilized to monitor the changes of ICAD during natural follow-up or medical treatment
The ICASMAP Intracranial Artery Stenosis MR Imaging Aetiology and Progression is a prospective cross-sectional observational and multicenter study The objectives of ICASMAP are to determine 1 the spectrum of etiology of ICAS in stroke patients and 2 the influence factors for progression of ICAD A total of 300 patients with symptomatic stenotic disease in intracranial arteries stenosis range 30-99 will be recruited within two weeks after symptom onset from 18 different hospitals across Beijing-Tianjin-Hebei region in China within 1 year All the patients will undergo HR-MRI for intracranial arteries at baseline one-year and two-years The clinical risk factors will be collected and blood draw will be conducted The ICASMAP study may help to improve the precise diagnosis and intervention of ICAS and stroke prevention
High-resolution magnetic resonance imaging HR-MRI has been widely used to assess ICAS diseases The different etiologies of ICAS are differentiable by MR-MRI according to the features of location shape signal pattern remodeling and contrast enhancement Investigators have proved that HR-MRI is a reproducible technique that may be reliably utilized to monitor the changes of ICAD during natural follow-up or medical treatment
The ICASMAP Intracranial Artery Stenosis MR Imaging Aetiology and Progression is a prospective cross-sectional observational and multicenter study The objectives of ICASMAP are to determine 1 the spectrum of etiology of ICAS in stroke patients and 2 the influence factors for progression of ICAD A total of 300 patients with symptomatic stenotic disease in intracranial arteries stenosis range 30-99 will be recruited within two weeks after symptom onset from 18 different hospitals across Beijing-Tianjin-Hebei region in China within 1 year All the patients will undergo HR-MRI for intracranial arteries at baseline one-year and two-years The clinical risk factors will be collected and blood draw will be conducted The ICASMAP study may help to improve the precise diagnosis and intervention of ICAS and stroke prevention
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None