Ignite Creation Date:
2024-05-06 @ 11:01 AM
Last Modification Date:
2024-10-26 @ 12:39 PM
Study NCT ID:
NCT03417700
Status:
COMPLETED
Last Update Posted:
2021-05-11
First Post:
2017-11-30
Brief Title:
Vitamin D as a Factor Modifying Adaptation to Exercise
Sponsor:
Gdansk University of Physical Education and Sport
Organization:
Gdansk University of Physical Education and Sport
Study Overview
Official Title:
Vitamin D as a Factor Modifying Adaptation to Diverse Forms of Exercise
Status:
COMPLETED
Status Verified Date:
2021-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Physical activity is a recommended indispensable element of a healthy lifestyle as well as a countermeasure against many diseases often accompanied by the acute or chronic low grade inflammation Papers published in recent years have demonstrated the anti-inflammatory effect of exercise Based on current knowledge of the topic own experience and preliminary work it is expected the proposed research to provide information on the mechanism either determining or limiting pro-healthy effects of exercise in different age groups of people Three different training programmes will be investigated Specific goals of the project include the following
1 Establish whether regular Nordic Walking training and HIIT can reduce the low-grade systemic inflammation and which type of training is the most effective at doing so
2 Establish whether regular training can prevent muscle sarcopenia and assess if those changes are related to the concentration of the autophagy-inducing stress protein HMGB1
3 Establish whether regular Nordic Walking training alters iron metabolism and evaluate its correlation with the inflammatory markers and bone-morphogenesis
4 Establish whether muscle-released irisin signals growth in the BDNF concentration in response to exercise and if these changes improve cognitive function
5 Establish whether Nordic Walking or HIIT training effectively improve the blood lipid profile and aerobic capacity and if these effects correlate with the blood 25-OHD concentration
6 Establish whether concentration of vitamin D alters adaptation to training and modifies immunological response to regular training process
1 Establish whether regular Nordic Walking training and HIIT can reduce the low-grade systemic inflammation and which type of training is the most effective at doing so
2 Establish whether regular training can prevent muscle sarcopenia and assess if those changes are related to the concentration of the autophagy-inducing stress protein HMGB1
3 Establish whether regular Nordic Walking training alters iron metabolism and evaluate its correlation with the inflammatory markers and bone-morphogenesis
4 Establish whether muscle-released irisin signals growth in the BDNF concentration in response to exercise and if these changes improve cognitive function
5 Establish whether Nordic Walking or HIIT training effectively improve the blood lipid profile and aerobic capacity and if these effects correlate with the blood 25-OHD concentration
6 Establish whether concentration of vitamin D alters adaptation to training and modifies immunological response to regular training process
Detailed Description:
The mechanism behind the anti-inflammatory effect of exercise is not fully understood In some cases physical activity has proven almostcompletely ineffective in reducing systemic inflammation Thus evaluating factors which modify this response is of particular significance One of them may be related to iron metabolism It is has been suggested that regular training reduces body iron stores which can contribute to the anti-inflammatory response Consequently one of the anti-inflammatory effects of exercise can be related to changes in iron metabolism Nevertheless our preliminary data demonstrated that eight months of Nordic Walking training did not reduce body iron stores in approx 25 of subjects even if some of them were characterized by high blood ferritin good indicator of body iron stores This may be related to the effect of exercise on the concentration of hepcidin main regulator of iron absorption which acts as a negative regulator of iron efflux It is well documented that a single bout of exercise induces an increase in blood hepcidin however data on the effect of regular training on the hepcidin concentration are limited
Vitamin D is another factor which could influence the anti-inflammatory effect of exercise It has been suggested that individuals involved in physical activity have higher concentrations of 25OHD indicator of vitamin D status Vitamin D inhibits the expression of pro-inflammatory cytokines which is considered the main mechanism of its anti-inflammatory action It is worth noting that population in Poland is characterized by low status of vitamin D Thus it is possible that the anti-inflammatory effect of exercise will be modified by the vitamin status Moreover vitamin D has been shown to protect against muscle atrophy both in elderly and younger people Its concentration has been correlated with muscle strength
Inflammation has been observed to be associated with an increase of the autophagy-inducing stress protein HMGB1 which mediates muscle atrophy Measurement of plasma amino acid profile will be helpful to assess the impact of exercise on muscle proteolysis Moreover the link between exercise vitamin D status and HMGB1 has not yet been established In addition a range of interactions induced by exercise involves the release of the newly discovered protein irisin form the muscle and its improving effect on the cognitive function through the synthesis of brain-derived neurotrophic factor BDNF Data on the effect of regular training on irisin concentration in elderly people is lacking
Overall our research interest focuses on the role of the factors mediating the anti-inflammatory effect of exercise and the way they stimulate or inhibit adaptive changes The proposed project draws on our long experience in investigating the effects of exercise on iron metabolism as well as other physical methods supporting the anti-inflammatory action of physical activity Latest published papers indicate that the concentration of vitamin D also in training adaptation can modulate immunological response to exercise Therefore verifying our hypothesis would also allow us to determine if the concentration of vitamin D can limit adaptation to physical activity
Vitamin D is another factor which could influence the anti-inflammatory effect of exercise It has been suggested that individuals involved in physical activity have higher concentrations of 25OHD indicator of vitamin D status Vitamin D inhibits the expression of pro-inflammatory cytokines which is considered the main mechanism of its anti-inflammatory action It is worth noting that population in Poland is characterized by low status of vitamin D Thus it is possible that the anti-inflammatory effect of exercise will be modified by the vitamin status Moreover vitamin D has been shown to protect against muscle atrophy both in elderly and younger people Its concentration has been correlated with muscle strength
Inflammation has been observed to be associated with an increase of the autophagy-inducing stress protein HMGB1 which mediates muscle atrophy Measurement of plasma amino acid profile will be helpful to assess the impact of exercise on muscle proteolysis Moreover the link between exercise vitamin D status and HMGB1 has not yet been established In addition a range of interactions induced by exercise involves the release of the newly discovered protein irisin form the muscle and its improving effect on the cognitive function through the synthesis of brain-derived neurotrophic factor BDNF Data on the effect of regular training on irisin concentration in elderly people is lacking
Overall our research interest focuses on the role of the factors mediating the anti-inflammatory effect of exercise and the way they stimulate or inhibit adaptive changes The proposed project draws on our long experience in investigating the effects of exercise on iron metabolism as well as other physical methods supporting the anti-inflammatory action of physical activity Latest published papers indicate that the concentration of vitamin D also in training adaptation can modulate immunological response to exercise Therefore verifying our hypothesis would also allow us to determine if the concentration of vitamin D can limit adaptation to physical activity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None