Ignite Creation Date:
2024-05-06 @ 11:00 AM
Last Modification Date:
2024-10-26 @ 12:38 PM
Study NCT ID:
NCT03407066
Status:
RECRUITING
Last Update Posted:
2023-10-18
First Post:
2018-01-20
Brief Title:
Perception Sensation Cognition and Action in Humans
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Perception Sensation Cognition and Action in Humans
Status:
RECRUITING
Status Verified Date:
2024-10-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
When people see and hear the brain changes signals from the eyes and ears into perceptions and thoughts No one fully understands how this happens Researchers want to explore how healthy brains process sights and sounds
Objectives
To explore how people understand what they see and hear when the brain processes sights and sounds
Eligibility
Adults ages 18-65 who have at least 2040 vision in at least one eye and do not use a hearing aid
Design
Some participants will take tests online anonymously They will do computer tasks related to colors and behavior
In-person participants will be screened with medical history and physical exam They will complete questionnaires and vision and hearing tests
Participants will plan how many testing sessions they will have and when Sessions last 2-5 hours They may include
Magnetic Resonance Imaging Magnets and radio waves to take pictures of the brain Participants will lie on a table that slides in and out of a tube They will do a task during the scan
Magnetoencephalography Records magnetic field changes from brain activity Participants will sit or lie down A cone will be lowered onto their head They may do a task during the test
Electromyography Electrodes attached to the skin will measure the electrical activity of muscles
Electroencephalogram Electrodes on the scalp will record brain waves
Electrocardiography Electrodes on the chest will record heart electrical activity
Tests of memory attention thinking vision and hearing
Eye Tracking Cameras will follow participants eye movements They may wear a cap with infrared cameras in front of their eyes
During the sessions participants vital signs may be monitored
When people see and hear the brain changes signals from the eyes and ears into perceptions and thoughts No one fully understands how this happens Researchers want to explore how healthy brains process sights and sounds
Objectives
To explore how people understand what they see and hear when the brain processes sights and sounds
Eligibility
Adults ages 18-65 who have at least 2040 vision in at least one eye and do not use a hearing aid
Design
Some participants will take tests online anonymously They will do computer tasks related to colors and behavior
In-person participants will be screened with medical history and physical exam They will complete questionnaires and vision and hearing tests
Participants will plan how many testing sessions they will have and when Sessions last 2-5 hours They may include
Magnetic Resonance Imaging Magnets and radio waves to take pictures of the brain Participants will lie on a table that slides in and out of a tube They will do a task during the scan
Magnetoencephalography Records magnetic field changes from brain activity Participants will sit or lie down A cone will be lowered onto their head They may do a task during the test
Electromyography Electrodes attached to the skin will measure the electrical activity of muscles
Electroencephalogram Electrodes on the scalp will record brain waves
Electrocardiography Electrodes on the chest will record heart electrical activity
Tests of memory attention thinking vision and hearing
Eye Tracking Cameras will follow participants eye movements They may wear a cap with infrared cameras in front of their eyes
During the sessions participants vital signs may be monitored
Detailed Description:
Objective
The experiments covered by this protocol aim to uncover basic knowledge about the normal brain mechanisms that give rise to perception and cognition The protocol encompasses sub-studies in healthy volunteers participants to uncover behaviors and their physiological basis
The protocol includes only non- or minimally-invasive techniques with minimal risk including psychophysics functional magnetic resonance imaging fMRI magnetoencephalography MEG genetic sequencing and on-line tests using Amazon s Mechanical Turk MTurk The overarching goal of the research is to obtain new knowledge in the organization and operation of cortical circuits involved in visual and auditory perception The protocol covers six specific inter-related aims with specific sub-studies
1 Neurophysiological Mechanisms for Color
2 Object-Color Associations Color Memory
3 Connectivity of Functionally-Defined Regions
4 Homologies between Monkeys and Humans
5 Functional Organization of Sound Perception and Visual-Auditory Integration
6 Multi-stability in Color Perception
Study Population
Normal volunteer participants aged 18-65 who are in good general health and have normal or corrected-to-normal vision will be recruited from the local community and studied under this minimal risk protocol We plan to recruit up to 200 in-person participants and up to 10000 on-line volunteers
Design
In some sub-studies the same subject will be asked to participate in tasks involving fMRI MEG and psychophysics and multiple sessions of each so that we can control for individual differences in relating the outcomes of each experimental technique In other sub-studies participation in multiple tasks will not be required The extent of the participant involvement and what they will be asked to do will be clearly disclosed during consent as indicated in the consent documents Brain activity of healthy human volunteers will be monitored by fMRI andor MEG Anatomical MRI will be collected in some subjects to allow better localization of brain dynamics Behavioral tests will be conducted using standard psychophysical approaches involving presentation of visual andor auditory stimuli while eye-movements are monitored using non-invasive eye tracking such as with an infra-red camera directed at the participant s eyes Subjects will be shown simple visual stimuli such as blobs stripes and spirals in assorted colors moving dots checkerboards and every-day images and video clips such as of fruit rolling on a table cloth faces and scenery recorded in a car Auditory stimuli will include every-day sounds such as birds singing conversation whispering footsteps car engines and animal vocalizations presented within normal sound limits 60- 90 dB We will not use provocative or sexually explicit images clips or sounds During fMRI and MEG sessions subjects will be asked to free view passively fixate or engage in an attentional task during fixation such as reporting with an eye movement or button press occasions when two images of the same category are presented sequentially
Outcome Measures
Performance on behavioral tasks and brain activity fMRI and MEG will be combined to yield information about the neural correlates and processes underlying different aspects of the human neural visual processing stream including color perception attention visual discrimination and objectfaceplace recognition
i MRI to analyze measures such as the anatomical structures of the brain using structural MRI amplitude of the blood-oxygenation-level-dependent BOLD signal using fMRI
ii MEG to quantify measures such as power spectrum event- or task-related potentials synchronizationdesynchronization and coherence between sensors or sources located close to the brain areas of interest
iii Behavioral measures to quantify measures such as hit rate reaction times thresholds similarity judgments associations naming such as names for color stimuli and sounds and eye movements
We may measure autonomic data during the course of the experiment such as heart rate respiration end-tidal CO2 skin conductance which will be correlated with the outcome measures
The experiments covered by this protocol aim to uncover basic knowledge about the normal brain mechanisms that give rise to perception and cognition The protocol encompasses sub-studies in healthy volunteers participants to uncover behaviors and their physiological basis
The protocol includes only non- or minimally-invasive techniques with minimal risk including psychophysics functional magnetic resonance imaging fMRI magnetoencephalography MEG genetic sequencing and on-line tests using Amazon s Mechanical Turk MTurk The overarching goal of the research is to obtain new knowledge in the organization and operation of cortical circuits involved in visual and auditory perception The protocol covers six specific inter-related aims with specific sub-studies
1 Neurophysiological Mechanisms for Color
2 Object-Color Associations Color Memory
3 Connectivity of Functionally-Defined Regions
4 Homologies between Monkeys and Humans
5 Functional Organization of Sound Perception and Visual-Auditory Integration
6 Multi-stability in Color Perception
Study Population
Normal volunteer participants aged 18-65 who are in good general health and have normal or corrected-to-normal vision will be recruited from the local community and studied under this minimal risk protocol We plan to recruit up to 200 in-person participants and up to 10000 on-line volunteers
Design
In some sub-studies the same subject will be asked to participate in tasks involving fMRI MEG and psychophysics and multiple sessions of each so that we can control for individual differences in relating the outcomes of each experimental technique In other sub-studies participation in multiple tasks will not be required The extent of the participant involvement and what they will be asked to do will be clearly disclosed during consent as indicated in the consent documents Brain activity of healthy human volunteers will be monitored by fMRI andor MEG Anatomical MRI will be collected in some subjects to allow better localization of brain dynamics Behavioral tests will be conducted using standard psychophysical approaches involving presentation of visual andor auditory stimuli while eye-movements are monitored using non-invasive eye tracking such as with an infra-red camera directed at the participant s eyes Subjects will be shown simple visual stimuli such as blobs stripes and spirals in assorted colors moving dots checkerboards and every-day images and video clips such as of fruit rolling on a table cloth faces and scenery recorded in a car Auditory stimuli will include every-day sounds such as birds singing conversation whispering footsteps car engines and animal vocalizations presented within normal sound limits 60- 90 dB We will not use provocative or sexually explicit images clips or sounds During fMRI and MEG sessions subjects will be asked to free view passively fixate or engage in an attentional task during fixation such as reporting with an eye movement or button press occasions when two images of the same category are presented sequentially
Outcome Measures
Performance on behavioral tasks and brain activity fMRI and MEG will be combined to yield information about the neural correlates and processes underlying different aspects of the human neural visual processing stream including color perception attention visual discrimination and objectfaceplace recognition
i MRI to analyze measures such as the anatomical structures of the brain using structural MRI amplitude of the blood-oxygenation-level-dependent BOLD signal using fMRI
ii MEG to quantify measures such as power spectrum event- or task-related potentials synchronizationdesynchronization and coherence between sensors or sources located close to the brain areas of interest
iii Behavioral measures to quantify measures such as hit rate reaction times thresholds similarity judgments associations naming such as names for color stimuli and sounds and eye movements
We may measure autonomic data during the course of the experiment such as heart rate respiration end-tidal CO2 skin conductance which will be correlated with the outcome measures
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 18-EI-0046 | None | None | None |