Ignite Creation Date:
2024-05-06 @ 10:57 AM
Last Modification Date:
2024-10-26 @ 12:38 PM
Study NCT ID:
NCT03399136
Status:
COMPLETED
Last Update Posted:
2022-12-06
First Post:
2018-01-04
Brief Title:
Fitness and Longevity in Exercise
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Fitness and Longevity in Exercise
Status:
COMPLETED
Status Verified Date:
2022-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FLEX
Brief Summary:
The study objective was to determine the safety and efficacy of aerobic exercise in older HIV-infected men in a randomized trial comparing different levels of exercise intensity
Detailed Description:
The study was a randomized trial of moderate-intensity versus high-intensity aerobic exercise AEX training in older HIV-infected adults Funding was provided by K23 AG024896 PI Oursler and the UMB Claude D Pepper Older Americans Independence Center P60 AG12583 PI Goldberg
The central hypothesis was that high-intensity AEX training is well-tolerated and significantly increases aerobic capacity in older HIV-infected adults
The study met its objectives
1 Scientific AIMS met
1 High-intensity AEX training significantly increases aerobic capacity
2 Both moderate-intensity and high-intensity AEX training improve ambulatory function and endurance
3 Activity of skeletal muscle oxidative enzymes is reduced and associated with aerobic capacity
2 Feasibility Objectives met
1 AEX training is safe and well-tolerated in older HIV-infected adults
2 Skeletal muscle punch biopsy is safe and well-tolerated in older HIV-infected adults
3 Preliminary data was collected on plasma biomarkers of inflammation
The central hypothesis was that high-intensity AEX training is well-tolerated and significantly increases aerobic capacity in older HIV-infected adults
The study met its objectives
1 Scientific AIMS met
1 High-intensity AEX training significantly increases aerobic capacity
2 Both moderate-intensity and high-intensity AEX training improve ambulatory function and endurance
3 Activity of skeletal muscle oxidative enzymes is reduced and associated with aerobic capacity
2 Feasibility Objectives met
1 AEX training is safe and well-tolerated in older HIV-infected adults
2 Skeletal muscle punch biopsy is safe and well-tolerated in older HIV-infected adults
3 Preliminary data was collected on plasma biomarkers of inflammation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None