Ignite Creation Date:
2024-05-06 @ 10:54 AM
Last Modification Date:
2024-10-26 @ 12:37 PM
Study NCT ID:
NCT03384303
Status:
COMPLETED
Last Update Posted:
2017-12-27
First Post:
2017-12-04
Brief Title:
Changes in Incretines Gut Hormones and Bile Acids After Roux-en-Y Gastric Bypass
Sponsor:
Rijnstate Hospital
Organization:
Rijnstate Hospital
Study Overview
Official Title:
Changes in Incretines Gut Hormones and Bile Acids After Roux-en-Y Gastric
Status:
COMPLETED
Status Verified Date:
2017-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Obesity is an increasing world wide problem Moreover the increase in patients who are considered morbidly obese is even higher Sturm et al Healt Aff 2004 Conservative approaches such as diets or medication are unsuccessful in the majority of the patients Additionally morbid obesity leads often to cardiovascular diseases such as hypertension dyslipidemia and type 2 diabetes T2DM When patients need insulin to regulate their glucose levels their weight is even more difficult to control Therefore bariatric procedures are increasingly performed with over 8000 procedures in the Netherlands in 2013 The two most performed types of bariatric surgery in the Netherlands are the Laparoscopic Roux-en-Y Gastric Bypass LRYGB and the Laparoscopic Sleeve Gastrectomy LSG Within the LRYGB there are different variants available In a recently initiated randomized controlled trial RCT from our centre a comparison between two variants of RYGB was performed In this RCT our standard RYGB s-RYGBalimentary limb AL of 150cm biliopancreatic limb BPL of 75cm was compared with a RYGB with an long BPL LBPLRYGBAL of 75cm and a BPL of 150cm A LBPLRYGB might improve weight loss and reduction after surgery The exact mechanism of action is still not fully understood Stomach volume is decreased and satiety levels often increase probably due to changes in incretin levels Passage of foods through the gastrointestinal tract are altered after RYGB A possible explanation might be found in different levels of incretins such as GLP-1 PYY and ghrelin and bile acids FGF-19 and FGF-21 after bariatric surgery
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None