Ignite Creation Date:
2024-05-06 @ 10:54 AM
Last Modification Date:
2024-10-26 @ 12:37 PM
Study NCT ID:
NCT03388463
Status:
COMPLETED
Last Update Posted:
2018-01-03
First Post:
2017-12-24
Brief Title:
Single Dose Omeprazole Versus High Dose in High-risk Critically Ill Patients
Sponsor:
Menoufia University
Organization:
Menoufia University
Study Overview
Official Title:
The Effectiveness of Standard Single Dose Omeprazole Versus High Dose Continuous Infusion in High-risk Critically Ill Patients
Status:
COMPLETED
Status Verified Date:
2017-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Upper gastrointestinal GIT bleeding is common in high risk critically ill patients Hyperacidity has been identified as one of the main reasons for bleeding1 2 Antacids with different treatment modalities have been studied to establish the best regimen for prophylaxis against bleeding3 4 Proton pump inhibitors PPI are the most common drugs used in the medical field as antacids The present study was carried out to investigate the beneficial effects of high dose omeprazole versus standard low dose as a prophylaxis against upper GIT bleeding in high risk critically ill patients
Detailed Description:
A hundred and ten high risk critically ill patients were divided into two groups fify five patients each Group A received intravenous IV omeprazole 40mg bolus dose once daily followed by normal saline infusion Group B received IV bolus of 80 mg omeprazole followed by 8mgh infusion The treatment was for the whole period of ICU stay Gastric pH residual gastric volume signs of significant upper GIT bleeding ICU stay Hb number of ventilator free days ICU stay haemoglobin Hb number of red cell units transfused in ICU ICU stay and numbers of ICU survivors were recorded
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None