Ignite Creation Date:
2024-05-06 @ 10:53 AM
Last Modification Date:
2024-10-26 @ 12:36 PM
Study NCT ID:
NCT03370926
Status:
UNKNOWN
Last Update Posted:
2017-12-13
First Post:
2017-11-30
Brief Title:
FET-PET and Multiparametric MRI for High-grade Glioma Patients Undergoing Radiotherapy
Sponsor:
University Hospital Brest
Organization:
University Hospital Brest
Study Overview
Official Title:
18F-Fluoroethyl-L-tyrosine Positron Emission Tomography and Multiparametric MRI for the Delination of Target Volumes in High-grade Glioma Patients Undergoing Radiotherapy
Status:
UNKNOWN
Status Verified Date:
2017-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IMAGG
Brief Summary:
Glioblastoma is the most common malignant brain tumor in adults The primary treatment consists of maximal tumor removal followed by radiotherapy RT with concomitant and adjuvant temozolomide Tumor recurrence after chemoradiotherapy has previously been shown to be predominantly within or at the margin of the irradiated volume but distant failure are not rare especially in patients with MGMT methylationTraditionally RT has been planned based on on planning CT with co-registered postoperative MRI with the addition of a clinical target volume margin of 2-3 cm to account for infiltrative odema
To better characterize the disease more specific physiological andor metabolical markers of tumor cells vascularization and hypoxia measured on multiparametric MRI as perfusion diffusion and spectroscopy alongside with PET tracer like Fluoroéthyl-L-tyrosine 18F-FET are now available and suggest that aggressive areas like uptake of PET tracer and vascularity are present outside areas of contrast enhancement usually irradiated These informations could be incorporated to optimize the treatment of radiotherapy
To better characterize the disease more specific physiological andor metabolical markers of tumor cells vascularization and hypoxia measured on multiparametric MRI as perfusion diffusion and spectroscopy alongside with PET tracer like Fluoroéthyl-L-tyrosine 18F-FET are now available and suggest that aggressive areas like uptake of PET tracer and vascularity are present outside areas of contrast enhancement usually irradiated These informations could be incorporated to optimize the treatment of radiotherapy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None