Ignite Creation Date:
2024-05-06 @ 10:53 AM
Last Modification Date:
2024-10-26 @ 12:36 PM
Study NCT ID:
NCT03370432
Status:
COMPLETED
Last Update Posted:
2017-12-19
First Post:
2017-12-06
Brief Title:
Vitamin D Genes and Colorectal Cancer
Sponsor:
University of Southern Denmark
Organization:
University of Southern Denmark
Study Overview
Official Title:
Associations Between Genetically Determined Low Vitamin D Level Vitamin D Intake and Risk of Colorectal Cancer in a Prospective Case-cohort Study in Danes
Status:
COMPLETED
Status Verified Date:
2017-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to investigate the interaction between intake of vitamin D and polymorphisms in GC and CYP2R1 in relation to risk of colorectal cancer in a Danish prospective cohort study
Detailed Description:
The association between vitamin D and incidence of colorectal cancer CRC has been thoroughly investigated in both observational and experimental studies but the results are conflicting Genetic epidemiology is an advantageous alternative to randomized clinical trials for ethical and economic reasons
The aim of this study is to investigate whether polymorphisms in GC and CYP2R1 that predicts 25-hydroxycholecalciferol 25OHD concentrations after both ultraviolet B radiation and consumption of vitamin D3-fortified bread and milk in Danes are associated with risk of CRC and further to examine whether intake of vitamin D through diet and supplementation alter the risk of CRC
Data are retrieved from the Danish prospective Diet Cancer and Health study encompassing 57053 persons which were recruited between 1993 to 1997 Between 1994 and 31th December 2009 1038 CRC cases has been diagnosed A sub-cohort of 1857 persons has been randomly selected within the full cohort at time of entry into the cohort The study design is a nested case-cohort study
The aim of this study is to investigate whether polymorphisms in GC and CYP2R1 that predicts 25-hydroxycholecalciferol 25OHD concentrations after both ultraviolet B radiation and consumption of vitamin D3-fortified bread and milk in Danes are associated with risk of CRC and further to examine whether intake of vitamin D through diet and supplementation alter the risk of CRC
Data are retrieved from the Danish prospective Diet Cancer and Health study encompassing 57053 persons which were recruited between 1993 to 1997 Between 1994 and 31th December 2009 1038 CRC cases has been diagnosed A sub-cohort of 1857 persons has been randomly selected within the full cohort at time of entry into the cohort The study design is a nested case-cohort study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None