Ignite Creation Date:
2024-05-05 @ 4:39 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00283907
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-01-29
Brief Title:
Brain Networks Responsible for Sense of Agency
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Brain Networks Responsible for Sense of Agency An EEG Study
Status:
COMPLETED
Status Verified Date:
2008-12-16
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study of healthy normal volunteers will examine the brain networks involved in peoples sense that they control their own movements sense of agency Although almost everyone has a sense of agency some patients for example patients with schizophrenia alien limb phenomena and others have movements they think are not under their control This study will use electroencephalography EEG to determine how the normal brain produces the sense of agency This information will provide a first step in understanding patients with an impaired sense of agency
Healthy right-handed men and women 18 years of age and older may be eligible for this study Candidates are screened with a medical history and neurological examination
Participants are fitted with a cyberglove device a lightweight glove with flexible sensors that measure the position and movement of the fingers and wrist on their right hand The glove is used to transform the subjects hand and finger motions into real-time digital joint-angle information Subjects slowly open and close their hand while watching an artificial hand projected on a monitor They continue practicing the exercise until they are comfortable with the cyberglove and have the sense that the artificial hand is a mirror representation of their own hand accurately reflecting their hands movements
After practicing with the cyberglove subjects have a functional EEG For this test electrodes are placed on the scalp and brain waves are recorded while the subject opens and closes his or her hand or just watches the computer monitor The EEG recording takes about 60 minutes
Healthy right-handed men and women 18 years of age and older may be eligible for this study Candidates are screened with a medical history and neurological examination
Participants are fitted with a cyberglove device a lightweight glove with flexible sensors that measure the position and movement of the fingers and wrist on their right hand The glove is used to transform the subjects hand and finger motions into real-time digital joint-angle information Subjects slowly open and close their hand while watching an artificial hand projected on a monitor They continue practicing the exercise until they are comfortable with the cyberglove and have the sense that the artificial hand is a mirror representation of their own hand accurately reflecting their hands movements
After practicing with the cyberglove subjects have a functional EEG For this test electrodes are placed on the scalp and brain waves are recorded while the subject opens and closes his or her hand or just watches the computer monitor The EEG recording takes about 60 minutes
Detailed Description:
Objective
The purpose of this study is to investigate spatiotemporal patterns of brain networks involved in the sense of agency using high-resolution electroencephalography EEG
Study Population
We intend to use 20 right-hand dominant adult healthy subjects
Design
The sense of agency SA will be modulated using a visual task-based stimulus asking subjects to manipulate the position of an artificial hand projected onto a display Subjects will use their own right hand to make slow openingclosing movements randomly which will be represented visually with the aid of a Cyberglove During a behavioral training phase subjects will practice using the apparatus The level of control will be randomly changed to one of five states 100 75 50 25 0 control For secondary analysis subjects will be asked to report the percentage of control they subjectively feel over the displayed hand After subjects are comfortable with the apparatus and endorse SA over the displayed hand they will undergo EEG
The experimental phase will have five sets of 10 minute recording sessions where the subject is instructed to slowly open and close their hand randomly The level of control will be changed pseudo-randomly throughout the recording sessions A control contrast consisting of the subject observing a moving hand will also be integrated into the blocks An additional control contrast involving the subject moving their hand without visual feedback will also be included These contrasts will serve in the analysis phase to help eliminate electrophysiological activity related to visual-motor feedback
A Magnetic Resonance Imaging MRI scan of brain will be performed to co-register this EEG data with the anatomical structure We will integrate physiological EEG and anatomical MRI data to characterize the regionalization of the task-related brain EEG activity
Outcome Measures
The primary outcome of this study is the effective connectivity of brain in response to a loss of SA For this purpose we will measure the difference of EEG power spectral analysis as well as coherence between 0 and 100 control In a secondary analysis we will investigate the correlation of the EEG measurements with the percent of actual control and also utilize the individual subject perceptions of percent control during the behavioral training phase as the regressors for activation rather than the objective control settings
The purpose of this study is to investigate spatiotemporal patterns of brain networks involved in the sense of agency using high-resolution electroencephalography EEG
Study Population
We intend to use 20 right-hand dominant adult healthy subjects
Design
The sense of agency SA will be modulated using a visual task-based stimulus asking subjects to manipulate the position of an artificial hand projected onto a display Subjects will use their own right hand to make slow openingclosing movements randomly which will be represented visually with the aid of a Cyberglove During a behavioral training phase subjects will practice using the apparatus The level of control will be randomly changed to one of five states 100 75 50 25 0 control For secondary analysis subjects will be asked to report the percentage of control they subjectively feel over the displayed hand After subjects are comfortable with the apparatus and endorse SA over the displayed hand they will undergo EEG
The experimental phase will have five sets of 10 minute recording sessions where the subject is instructed to slowly open and close their hand randomly The level of control will be changed pseudo-randomly throughout the recording sessions A control contrast consisting of the subject observing a moving hand will also be integrated into the blocks An additional control contrast involving the subject moving their hand without visual feedback will also be included These contrasts will serve in the analysis phase to help eliminate electrophysiological activity related to visual-motor feedback
A Magnetic Resonance Imaging MRI scan of brain will be performed to co-register this EEG data with the anatomical structure We will integrate physiological EEG and anatomical MRI data to characterize the regionalization of the task-related brain EEG activity
Outcome Measures
The primary outcome of this study is the effective connectivity of brain in response to a loss of SA For this purpose we will measure the difference of EEG power spectral analysis as well as coherence between 0 and 100 control In a secondary analysis we will investigate the correlation of the EEG measurements with the percent of actual control and also utilize the individual subject perceptions of percent control during the behavioral training phase as the regressors for activation rather than the objective control settings
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 06-N-0084 | None | None | None |