Ignite Creation Date:
2024-05-06 @ 10:51 AM
Last Modification Date:
2024-10-26 @ 12:36 PM
Study NCT ID:
NCT03373955
Status:
UNKNOWN
Last Update Posted:
2021-03-18
First Post:
2017-11-23
Brief Title:
A Prospective Study of Constructing Immune Repertoire to Monitor the Therapeutic Effect in NSCLC Patients
Sponsor:
Sichuan University
Organization:
Sichuan University
Study Overview
Official Title:
A Prospective Study of Constructing Immune Repertoire Using Next-generation Sequencing NGS to Monitor the Therapeutic Effect in NSCLC Patients
Status:
UNKNOWN
Status Verified Date:
2021-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to evaluate the untreated NSCLC patients After participants have accepted chemotherapy radiotherapy and immunotherapy the investigators used the next generation sequence technology NGS to construct immune repertoire to detective variation of patients immune state and to monitor patients therapeutic effect The investigators are aim to explore the novel clone sequence as potential therapy target
Detailed Description:
Lung cancer was one of the most deadly tumors in the world The standard of care for patients is platinum-based doublet chemotherapy concurrent with radiotherapy As for patients with a mutant epidermal growth factor receptor EGFR and anaplastic lymphoma kinaseALK EGFR or ALK tyrosine kinase inhibitors TKIs are the standard first-line therapy Now the Food and Drug Administration approved Ipilimumab Nivolumab and Pembrolizumab as first-line or second-line therapy for NSCLC However there was no reports about therapeutic effect for NSCLC patients through detecting herself immune state immune repertoire could explore patients immune clonality and diversity using NGS technologyThe investigators look forward to illuminate the mechanism of patients antitumor action
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None