Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005398
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-01-31
First Post:
2000-05-25
Brief Title:
University of North Carolina Alumni Heart Study
Sponsor:
Duke University
Organization:
Duke University
Study Overview
Official Title:
University of North Carolina Alumni Heart Study
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To continue surveillance of the participants in the University of North Carolina Alumni Heart Study which tests the hypothesis that hostility and related psychosocial factors are involved in the pathogenesis of coronary heart disease
Detailed Description:
BACKGROUND
Prevention of coronary heart disease CHD will be enhanced by controlling hypertension reducing blood cholesterol maintaining normal weight increasing physical activity reducing smoking and having a healthy diet Understanding how to achieve these important public health aims requires an understanding of the behavioral factors involved in prevention Behavioral risk factors remain the single most preventable cause of human illness and suffering The University of North Carolina Alumni Heart Study is ideally suited to explore the associations between and among these important behavioral risk factors and to understand how personality in particular individual differences in hostility and depression act to determine individuals risk factor behaviors and to answer important questions about the role of hostility and psychosocial factors in CHD risk during the middle years
The University of North Carolina Alumni Heart Study UNCAHS is a prospective study of the role of psychosocial factors in particular hostility in the development of coronary heart disease The target population is composed of persons who completed the Minnesota Multiphasic Personality Inventory while attending the University of North Carolina in the mid-1960s
DESIGN NARRATIVE
Surveillance of the members of the UNC Alumni Heart Study continues for an additional five-year period Studies continue on how hostility and other psychosocial factors are related to each other and how they contribute to coronary heart disease risk Data are analyzed in order to test hypotheses about the role of psychosocial factors in weight parameters dietary practices and the contribution of spouse hostility to coronary risk
To better understand the dynamic interrelationships of psychosocial and behavioral risk factors of the adult life span the trajectories of hostility depression smoking body mass exercise patterns and alcohol consumption will be mapped using multiple assessments from age 19 to age 60 It is predicted that a significant proportion of the change in risk behavior will be due to trajectories of hostility and depression operating singly and in combination over time Tests will be made of the prospective associations of hostility depression and other psychosocial variables eg social support and job strain with coronary events and mortality observed while the cohort is middle-aged The scope of the psychosocial variables will be broadened to examine individual differences in personality over the life course and dietary practices at midlife in addition to the indicators noted above The effect of gender on the natural history of coronary disease and coronary risk profiles in women will be examined by monitoring changes in menopausal status and patterns of hormone replacement therapy use among women during midlife and the associations of these factors with the other risk indicators
Prevention of coronary heart disease CHD will be enhanced by controlling hypertension reducing blood cholesterol maintaining normal weight increasing physical activity reducing smoking and having a healthy diet Understanding how to achieve these important public health aims requires an understanding of the behavioral factors involved in prevention Behavioral risk factors remain the single most preventable cause of human illness and suffering The University of North Carolina Alumni Heart Study is ideally suited to explore the associations between and among these important behavioral risk factors and to understand how personality in particular individual differences in hostility and depression act to determine individuals risk factor behaviors and to answer important questions about the role of hostility and psychosocial factors in CHD risk during the middle years
The University of North Carolina Alumni Heart Study UNCAHS is a prospective study of the role of psychosocial factors in particular hostility in the development of coronary heart disease The target population is composed of persons who completed the Minnesota Multiphasic Personality Inventory while attending the University of North Carolina in the mid-1960s
DESIGN NARRATIVE
Surveillance of the members of the UNC Alumni Heart Study continues for an additional five-year period Studies continue on how hostility and other psychosocial factors are related to each other and how they contribute to coronary heart disease risk Data are analyzed in order to test hypotheses about the role of psychosocial factors in weight parameters dietary practices and the contribution of spouse hostility to coronary risk
To better understand the dynamic interrelationships of psychosocial and behavioral risk factors of the adult life span the trajectories of hostility depression smoking body mass exercise patterns and alcohol consumption will be mapped using multiple assessments from age 19 to age 60 It is predicted that a significant proportion of the change in risk behavior will be due to trajectories of hostility and depression operating singly and in combination over time Tests will be made of the prospective associations of hostility depression and other psychosocial variables eg social support and job strain with coronary events and mortality observed while the cohort is middle-aged The scope of the psychosocial variables will be broadened to examine individual differences in personality over the life course and dietary practices at midlife in addition to the indicators noted above The effect of gender on the natural history of coronary disease and coronary risk profiles in women will be examined by monitoring changes in menopausal status and patterns of hormone replacement therapy use among women during midlife and the associations of these factors with the other risk indicators
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL055356 | NIH | None | None |
| P01HL036587 | NIH | None | None |
| R01MH066079 | NIH | None | None |
| 4311 | US NIH GrantContract | None | httpsreporternihgovquickSearchR01MH066079 |