Ignite Creation Date:
2024-05-06 @ 10:51 AM
Last Modification Date:
2024-10-26 @ 12:36 PM
Study NCT ID:
NCT03368300
Status:
UNKNOWN
Last Update Posted:
2017-12-11
First Post:
2017-11-24
Brief Title:
Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans
Sponsor:
Centre Hospitalier Universitaire de Pointe-a-Pitre
Organization:
Centre Hospitalier Universitaire de Pointe-a-Pitre
Study Overview
Official Title:
Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans
Status:
UNKNOWN
Status Verified Date:
2017-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CAP
Brief Summary:
The primary aim of this study is to estimate the frequency and to characterize clinically atypical parkinsonism in the French West Indies and Guyana
Detailed Description:
An atypical akineto-rigid parkinsonian syndrome unresponsive to L-dopa has been evidenced in Guadeloupe Abnormally frequent this progressive supranuclear palsy PSP-like syndrome represents a new clinical entity Unlike in classical PSP 70 of patients have myoclonus 59 hallucinations 78 REM sleep behavior disorders Oculomotor pattern differs from classical PSP suggesting that cortical dysfunction predominates over brainstem impairments Neuropathological examination in four patients has shown a widespread accumulation of the tau protein in the basal ganglia the midbrain and cortical areas
This syndrome has been associated to the regular consumption of food products derived from plants of the Annonaceae family more specifically Annona Muricata soursop suggesting a toxic origin We have already confirmed the neurotoxic potential of the lipophilic mitochondrial complex I inhibitor annonacin the major acetogenin in Annona muricata This class of compounds is specific to Annonaceae Nanomolar concentrations of annonacin induce the death of dopaminergic neurons in culture by impairment of energy production Chronic systemic intoxication of rats with annonacin causes neuronal damage in the same brain regions that are damaged in patients with atypical parkinsonism These results greatly suggest that the consumption of annonacea might contribute to the pathogenesis of the disease The H1 subhaplotype in tau gene associated with PSP in Caucasians did not confer risk for PSP-like atypical parkinsonism in Guadeloupe
This syndrome has been associated to the regular consumption of food products derived from plants of the Annonaceae family more specifically Annona Muricata soursop suggesting a toxic origin We have already confirmed the neurotoxic potential of the lipophilic mitochondrial complex I inhibitor annonacin the major acetogenin in Annona muricata This class of compounds is specific to Annonaceae Nanomolar concentrations of annonacin induce the death of dopaminergic neurons in culture by impairment of energy production Chronic systemic intoxication of rats with annonacin causes neuronal damage in the same brain regions that are damaged in patients with atypical parkinsonism These results greatly suggest that the consumption of annonacea might contribute to the pathogenesis of the disease The H1 subhaplotype in tau gene associated with PSP in Caucasians did not confer risk for PSP-like atypical parkinsonism in Guadeloupe
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None