Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005377
Status:
COMPLETED
Last Update Posted:
2021-10-01
First Post:
2000-05-25
Brief Title:
Molecular Epidemiology of Essential Hypertension
Sponsor:
The University of Texas Health Science Center Houston
Organization:
The University of Texas Health Science Center Houston
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To localize individual genes called blood pressure quantitative trait genes BPQTGs which influence blood pressure levels in the population-at- large and to determine if these genes are able to predict the occurrence of essential hypertension or coronary artery disease
Detailed Description:
BACKGROUND
Essential hypertension reaches epidemic proportions among adults and is a significant risk factor for premature coronary artery disease CAD and stroke The research to localize BPQTGs represents an initial step toward applying DNA information to early identification of at-risk individuals and understanding the complex relationships among blood pressure essential hypertension and coronary artery disease
DESIGN NARRATIVE
The study has four aims Aim 1 uses robust sibling pair linkage methods parental marker data and office blood pressure levels measured on 1376 full sibling pairs to localize BPQTGs to regions of the human genome marked by highly polymorphic tandem repeat loci in or very near to 59 genes involved in blood pressure regulation These genes were selected based on their involvement in the reninangiotensin system ion transport cardiac physiology biometabolism of neurotransmitters or carbohydrate and lipid metabolism At each gene a highly polymorphic tandem repeat marker locus has already been identified Aim 2 uses methods of association analysis for related individuals and office blood pressure levels measured on 587 full sibships to localize BPQTGs to regions of the human genome marked by the 59 candidate BPQTGs Aim 3 determines if variation in these BPQTGs improves the ability to predict differences in blood pressure levels in a sample of 1166 unrelated normotensive adults or essential hypertension status in a sample of 1160 unrelated grandparents beyond that provided by established predictors Aim 4 determines if variation in these BPQTGs improves the ability to predict symptomatic or asymptomatic coronary artery disease status beyond that provided by established predictors including blood pressure and essential hypertension Aims 3 and 4 also ask whether the predictive relationship of the traditional risk factors to blood pressure essential hypertension or coronary artery disease is different among genotypes at these BPQTGs
The study was renewed in FY 1999 to continue data analysis
Essential hypertension reaches epidemic proportions among adults and is a significant risk factor for premature coronary artery disease CAD and stroke The research to localize BPQTGs represents an initial step toward applying DNA information to early identification of at-risk individuals and understanding the complex relationships among blood pressure essential hypertension and coronary artery disease
DESIGN NARRATIVE
The study has four aims Aim 1 uses robust sibling pair linkage methods parental marker data and office blood pressure levels measured on 1376 full sibling pairs to localize BPQTGs to regions of the human genome marked by highly polymorphic tandem repeat loci in or very near to 59 genes involved in blood pressure regulation These genes were selected based on their involvement in the reninangiotensin system ion transport cardiac physiology biometabolism of neurotransmitters or carbohydrate and lipid metabolism At each gene a highly polymorphic tandem repeat marker locus has already been identified Aim 2 uses methods of association analysis for related individuals and office blood pressure levels measured on 587 full sibships to localize BPQTGs to regions of the human genome marked by the 59 candidate BPQTGs Aim 3 determines if variation in these BPQTGs improves the ability to predict differences in blood pressure levels in a sample of 1166 unrelated normotensive adults or essential hypertension status in a sample of 1160 unrelated grandparents beyond that provided by established predictors Aim 4 determines if variation in these BPQTGs improves the ability to predict symptomatic or asymptomatic coronary artery disease status beyond that provided by established predictors including blood pressure and essential hypertension Aims 3 and 4 also ask whether the predictive relationship of the traditional risk factors to blood pressure essential hypertension or coronary artery disease is different among genotypes at these BPQTGs
The study was renewed in FY 1999 to continue data analysis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R37HL051021-15 | NIH | None | httpsreporternihgovquickSearchR37HL051021-15 |