Ignite Creation Date:
2024-05-06 @ 10:51 AM
Last Modification Date:
2024-10-26 @ 12:36 PM
Study NCT ID:
NCT03362385
Status:
COMPLETED
Last Update Posted:
2021-09-05
First Post:
2017-11-07
Brief Title:
OSA-ACS Project Association of OSA and CPAP Therapy With Outcomes in ACS Patients
Sponsor:
Beijing Anzhen Hospital
Organization:
Beijing Anzhen Hospital
Study Overview
Official Title:
Impact of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Therapy on Outcomes in Patients With Acute Coronary Syndrome The OSA-ACS Project
Status:
COMPLETED
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Obstructive sleep apnea OSA is an increasingly common chronic disorder in adults that has been strongly associated with various forms of cardiovascular disease Compared to the general population OSA occurs more often in patients with acute coronary syndrome ACS Although percutaneous coronary intervention PCI is nowadays part of standard therapy and optimal medical therapy has been used to manage traditional risk factors the long-term cardiovascular outcomes after index ACS remain suboptimal
Some preliminary data suggest OSA is associated with higher risk of subsequent cardiovascular events in ACS patients However the study population was heterogeneous and these studies were not done in the context of new-generation drug-eluting stents and intensive antiplatelet therapy thus precluding definite conclusions Furthermore a cardioprotective role of OSA in the context of acute myocardial infarction AMI via ischemic preconditioning has also been postulated
Due to the inconsistent evidence the investigators performed a large-scale prospective cohort study to delineate the whole picture of the association of OSA with short- and long-term outcomes of patients with ACS Whether treatment of OSA eg continuous positive airway pressure CPAP would prevent these events will also be evaluated Moreover the investigators will assess the potential mechanisms of OSA-induced atherosclerosis and myocardial injury in ACS patients
Some preliminary data suggest OSA is associated with higher risk of subsequent cardiovascular events in ACS patients However the study population was heterogeneous and these studies were not done in the context of new-generation drug-eluting stents and intensive antiplatelet therapy thus precluding definite conclusions Furthermore a cardioprotective role of OSA in the context of acute myocardial infarction AMI via ischemic preconditioning has also been postulated
Due to the inconsistent evidence the investigators performed a large-scale prospective cohort study to delineate the whole picture of the association of OSA with short- and long-term outcomes of patients with ACS Whether treatment of OSA eg continuous positive airway pressure CPAP would prevent these events will also be evaluated Moreover the investigators will assess the potential mechanisms of OSA-induced atherosclerosis and myocardial injury in ACS patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None