Ignite Creation Date:
2024-05-06 @ 10:49 AM
Last Modification Date:
2024-10-26 @ 12:35 PM
Study NCT ID:
NCT03354624
Status:
COMPLETED
Last Update Posted:
2018-03-05
First Post:
2017-11-19
Brief Title:
Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity
Sponsor:
Aalborg University
Organization:
Aalborg University
Study Overview
Official Title:
Cortical Neuroplasticity by Muscle Pain and Non-invasive Modulation of Pain-induced Plasticity
Status:
COMPLETED
Status Verified Date:
2018-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness DOMS on Extensor Carpi Radialis ECR muscle during muscle hyperalgesia provoked by nerve growth factor NGF
Detailed Description:
The purpose of this study is to assess changes in sensory-motor cortical excitability during experimental muscle hyperalgesia across several days provoked by injections of nerve growth factor NGF into the Extensor Carpi Radialis ECR muscle and delayed onset muscle soreness DOMS of the ECR muscle
It was hypothesized that muscle hyperalgesia across several days would result in
i Increased sensory cortical excitability based on somatosensory evoked potentials by means of electrical stimulation of the radial nerve increase of central-parietal evoked-potential P45 and decrease of frontal evoked-potential N30 ii Increased corticomotor excitability of a ECR increase map volume and number of active sites assessed as motor evoked potentials induced by transcranial magnetic stimulation in primary motor cortex M1 iii Reduction of alpha oscillation based on nociceptive stimulus-evoked suppression of alpha activity in sensory regions recording electrodes on contra-lateral parietal area
It was hypothesized that muscle hyperalgesia across several days would result in
i Increased sensory cortical excitability based on somatosensory evoked potentials by means of electrical stimulation of the radial nerve increase of central-parietal evoked-potential P45 and decrease of frontal evoked-potential N30 ii Increased corticomotor excitability of a ECR increase map volume and number of active sites assessed as motor evoked potentials induced by transcranial magnetic stimulation in primary motor cortex M1 iii Reduction of alpha oscillation based on nociceptive stimulus-evoked suppression of alpha activity in sensory regions recording electrodes on contra-lateral parietal area
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None