Ignite Creation Date:
2024-05-05 @ 1:18 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005242
Status:
COMPLETED
Last Update Posted:
2016-02-29
First Post:
2000-05-25
Brief Title:
Childhood Passive Smoking Cohort Study of Cardiac Risk
Sponsor:
Virginia Commonwealth University
Organization:
Virginia Commonwealth University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the effects of long-term exposure to passive smoking on the cardiovascular and oxygen transport systems in pre-adolescent twins
Detailed Description:
BACKGROUND
The adverse health effects of actively inhaled cigarette smoke include impaired pulmonary function increased coronary and cerebrovascular disease chronic pulmonary disease and cancer Infants and young children of smoking parents are at increased risk for lower respiratory tract infections and small airways disease than are children of non-smoking parents What is less clear is how the oxygen transport system of the growing child is affected by the long-term exposure to and passive inhalation of cigarette smoke and if this exposure represents a risk for the subsequent development of atherosclerotic heart disease
DESIGN NARRATIVE
A sample of 300 pre-adolescent twin pairs was recruited from an established population-based twin study The three cohorts of twins and their parents were initially evaluated in a cross-sectional study and then followed longitudinally for up to three years In the initial testing cycle the following data were collected genotype general health anthropometric measures resting and exercise noninvasive evaluation of hemodynamic parameters including blood pressure heart rate cardiac output left ventricular mass and oxygen consumption hematocrit and blood levels of 23-DPG cotinine thiocyanate and erythropoietin spirometric and pulmonary flow data lipid levels There were three follow-up exams The availability of repeated measures of oxygen delivery and its determinants in twins and their parents permitted both a unique analysis of genetic and environmental factors during the process of developmental change and measurements of the risks of accelerated atheroscleroticischemic heart disease and of the development of reactive airway disease
The following hypotheses were tested genetic factors accounted for a significant proportion of the variation in the hematologic and cardiovascular determinants of systemic oxygen delivery adaptive responses of the oxygen delivery system differed in the same individual before and after puberty passive smoking in children was an incremental risk factor for the development of accelerated atheroscleroticischemic cardiovascular disease passive smoking in children was a contributing factor in the development of reactive airway disease
The adverse health effects of actively inhaled cigarette smoke include impaired pulmonary function increased coronary and cerebrovascular disease chronic pulmonary disease and cancer Infants and young children of smoking parents are at increased risk for lower respiratory tract infections and small airways disease than are children of non-smoking parents What is less clear is how the oxygen transport system of the growing child is affected by the long-term exposure to and passive inhalation of cigarette smoke and if this exposure represents a risk for the subsequent development of atherosclerotic heart disease
DESIGN NARRATIVE
A sample of 300 pre-adolescent twin pairs was recruited from an established population-based twin study The three cohorts of twins and their parents were initially evaluated in a cross-sectional study and then followed longitudinally for up to three years In the initial testing cycle the following data were collected genotype general health anthropometric measures resting and exercise noninvasive evaluation of hemodynamic parameters including blood pressure heart rate cardiac output left ventricular mass and oxygen consumption hematocrit and blood levels of 23-DPG cotinine thiocyanate and erythropoietin spirometric and pulmonary flow data lipid levels There were three follow-up exams The availability of repeated measures of oxygen delivery and its determinants in twins and their parents permitted both a unique analysis of genetic and environmental factors during the process of developmental change and measurements of the risks of accelerated atheroscleroticischemic heart disease and of the development of reactive airway disease
The following hypotheses were tested genetic factors accounted for a significant proportion of the variation in the hematologic and cardiovascular determinants of systemic oxygen delivery adaptive responses of the oxygen delivery system differed in the same individual before and after puberty passive smoking in children was an incremental risk factor for the development of accelerated atheroscleroticischemic cardiovascular disease passive smoking in children was a contributing factor in the development of reactive airway disease
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R29HL038878 | NIH | None | httpsreporternihgovquickSearchR29HL038878 |