Ignite Creation Date:
2024-05-05 @ 4:39 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00280462
Status:
COMPLETED
Last Update Posted:
2008-07-09
First Post:
2006-01-19
Brief Title:
Choroidal Blood Flow Regulation During Isometric Exercise Effects of Ca2-Channel Blockade
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Choroidal Blood Flow Regulation During Isometric Exercise Effects of Ca2-Channel Blockade
Status:
COMPLETED
Status Verified Date:
2008-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure For a long time it had been assumed that the choroid is a strictly passive vascular bed which shows no autoregulation However recently several groups have identified some autoregulatory capacity of the human choroid In the brain and the retina the mechanism behind autoregulation is most likely linked to changes in transmural pressure In this model arterioles change their vascular tone depending on the pressure inside the vessel and outside the vessel In the choroid several observations argue against a direct involvement of arterioles In a previous project we were able to identify that the nitric oxide NO - system as well as the endothelin system are involved in choroidal blood flow regulation during isometric exercise
In the present study autoregulation of the choroid during isometric exercise will be investigated and the pressureflow relationships will be observed in the absence or presence of a calcium antagonist - nifedipine
In the present study autoregulation of the choroid during isometric exercise will be investigated and the pressureflow relationships will be observed in the absence or presence of a calcium antagonist - nifedipine
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None