Ignite Creation Date:
2024-05-06 @ 10:44 AM
Last Modification Date:
2024-10-26 @ 12:34 PM
Study NCT ID:
NCT03336385
Status:
COMPLETED
Last Update Posted:
2018-08-23
First Post:
2017-09-14
Brief Title:
Prebiotic Supplementation and Intestinal Barrier Function in Elderly a RCT
Sponsor:
Örebro University Sweden
Organization:
Örebro University Sweden
Study Overview
Official Title:
The Influence of Prebiotic Supplementation on Intestinal Barrier Function in Elderly A Randomized Placebo Controlled Clinical Trial
Status:
COMPLETED
Status Verified Date:
2018-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators aim was to assess whether 6 weeks of oral intake of the wheat-derived prebiotic fiber arabinoxylan or oat-derived beta-glucan could improve intestinal barrier function against drug-induced barrier disruption in a general population of elderly people in a randomized double blinded placebo-controlled clinical trial
Detailed Description:
The study consisted of a 9 week clinical trial to which the study participants orally ingested two different prebiotic compoundsone placebo for a total of 6 weeks
The primary outcome was intestinal permeability which was measured beforeafter indomethacin intake before starting with the prebiotic supplementation and repeated 6 weeks afterwards
Indomethacin is an NSAID known to artificially increase the intestinal permeability The prebiotic fibers arabinoxylan and oat-derived beta-glucan have not been investigated for their effect on intestinal permeability in older adults
Intestinal permeability was investigated using the multi-sugar permeability test Participants ingested a water solution containing 5 sugar probes that are taken up in different parts of the gut These sugars are later recovered in the urine at two different time points reflecting gastroduodenal small intestinal and colonic permeability
The primary outcome was intestinal permeability which was measured beforeafter indomethacin intake before starting with the prebiotic supplementation and repeated 6 weeks afterwards
Indomethacin is an NSAID known to artificially increase the intestinal permeability The prebiotic fibers arabinoxylan and oat-derived beta-glucan have not been investigated for their effect on intestinal permeability in older adults
Intestinal permeability was investigated using the multi-sugar permeability test Participants ingested a water solution containing 5 sugar probes that are taken up in different parts of the gut These sugars are later recovered in the urine at two different time points reflecting gastroduodenal small intestinal and colonic permeability
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None