Ignite Creation Date:
2024-05-06 @ 10:40 AM
Last Modification Date:
2024-10-26 @ 12:33 PM
Study NCT ID:
NCT03322618
Status:
COMPLETED
Last Update Posted:
2022-09-01
First Post:
2017-10-17
Brief Title:
Evaluation of the Expression and Functions of the KIR3DL2 Receptor and the Anti-inflammatory Activity of IPH4102 in Blood Samples
Sponsor:
Assistance Publique Hopitaux De Marseille
Organization:
Assistance Publique Hopitaux De Marseille
Study Overview
Official Title:
Evaluation of the Expression and Functions of the KIR3DL2 Receptor and the Anti-inflammatory Activity of IPH4102 Monoclonal Antibody IPH4102 Targeting KIR3DL2 in Blood Samples Taken From Patients With Axial Spondyloarthritis and Healthy Volunteers
Status:
COMPLETED
Status Verified Date:
2022-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
KIR3DL2
Brief Summary:
the main objectives are
1 to study the pathophysiological role of KIR3DL2 in axSpA and its relationship with Th17 immunity in HLA-B27 and HLA-B27- patients and
2 to assess the effect on the pro-inflammatory immune response of a cytotoxic monoclonal antibody IPH4102 anti-KIR3DL2 in these patients
The study will be carried out on blood samples from 24 patients with axSpA 12 HLA-B27 and 12 HLA-B27- without any drug injection nor direct therapeutic benefit for the participating patients and 12 healthy controls
1 to study the pathophysiological role of KIR3DL2 in axSpA and its relationship with Th17 immunity in HLA-B27 and HLA-B27- patients and
2 to assess the effect on the pro-inflammatory immune response of a cytotoxic monoclonal antibody IPH4102 anti-KIR3DL2 in these patients
The study will be carried out on blood samples from 24 patients with axSpA 12 HLA-B27 and 12 HLA-B27- without any drug injection nor direct therapeutic benefit for the participating patients and 12 healthy controls
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2017-A01705-48 | OTHER | NIDRCB | None |