Ignite Creation Date:
2024-05-05 @ 4:38 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00285896
Status:
COMPLETED
Last Update Posted:
2008-07-11
First Post:
2006-02-01
Brief Title:
GLP-1 Infusion and Long-Time Fasting
Sponsor:
University of Aarhus
Organization:
University of Aarhus
Study Overview
Official Title:
The Effect of 48 Hours of GLP-1 Infusion During Long-Time Fasting on Glycaemia and Counterregulatory Hormones
Status:
COMPLETED
Status Verified Date:
2008-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
GLP-1 is an incretin hormone that simulates insulin secretion and inhibits glucagon secretion in a glucose dependent way Below normal plasma glucose levels the effects of GLP-1 stop and the risk of hypoglycemia is small However no results exits on the effects pharmacologically relevant doses of GLP-1 during long-time fasting There seems to be a risk of hypoglycemia in healthy people after a fasting period when a glucose load is administered The risk of hypoglycemia when GLP-1 is administered will be evaluated during these two conditions
Detailed Description:
GLP-1 is an incretin hormone that simulates insulin secretion and inhibits glucagon secretion dependent on a normal plasma glucoseIt also inhibits gastric emptying and has a trophic effect on the pancreatic beta-cells Below normal plasma glucose levels the effects of GLP-1 stop and the risk of hypoglycemia is smallThe counter regulatory response to hypoglycemia has been shown to be preserved during GLP-1 infusion However no results exits on the effects pharmacologically relevant doses of GLP-1 during long-time fasting There seems to be a risk of hypoglycemia in healthy people after a fasting period when a glucose load is administered The risk of hypoglycemia when GLP-1 is administered will be evaluated during these two48 hours of fasting followed by a glucose-loadconditions in healthy men
Also the effect on 24 hour blood pressure will be evaluated
Also the effect on 24 hour blood pressure will be evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None