Ignite Creation Date:
2024-05-06 @ 10:37 AM
Last Modification Date:
2024-10-26 @ 12:33 PM
Study NCT ID:
NCT03308331
Status:
WITHDRAWN
Last Update Posted:
2020-03-10
First Post:
2017-10-07
Brief Title:
HIV-1 and Brain Interaction on Smoking Comorbidity
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
HIV-1 and Brain Interaction on Smoking Comorbidity
Status:
WITHDRAWN
Status Verified Date:
2020-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
We originally had a collaboration with a PI but he has left the University
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
People living with HIV-1 have high rates of cigarette smoking which may be related to nicotinic interaction with HIV-1 infection and brain function levels The proposed project aims to understand these pathways using translational brain imaging and HIV-1 reactivation studies The study proposes a targeted nicotine-brain investigation of the nicotinic effects in HIV-1 infection from cellular to brain circuitry levels
Detailed Description:
Smoking remains the leading cause of preventable morbidity and mortality in the United States The alarmingly high smoking rates and unsatisfactory performance of standard smoking cessation efforts in people living with HIVAIDS PLWH interfere with the overall progress in the treatment of HIV-1 infection Our understanding of nicotine addiction mechanisms in PLWH and how they are related to and interact with HIV-1 neuropathology is limited and thus hindering the development of more effective targeted treatments The study will directly address neurological complication of this HIV-associated comorbidity at the brain circuitry level using state-of-the-art imaging tools and methods
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None