Ignite Creation Date:
2024-05-06 @ 10:37 AM
Last Modification Date:
2024-10-26 @ 12:32 PM
Study NCT ID:
NCT03303404
Status:
COMPLETED
Last Update Posted:
2020-12-22
First Post:
2017-10-02
Brief Title:
24-hour Blood Pressure Measurements and Ischemic Conditioning
Sponsor:
University of Texas at Austin
Organization:
University of Texas at Austin
Study Overview
Official Title:
24-hour Blood Pressure Measurements and Ischemic Conditioning
Status:
COMPLETED
Status Verified Date:
2020-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine if 24-hr ambulatory blood pressure monitoring effects endothelial function we will measure flow-mediated dilation before and after the blood pressure monitoring ischemia conditioning
Detailed Description:
Reestablishing blood flow reperfusion to organs that had their blood supply restricted ischemia can cause damage to the vasculature via injury and tissue death resulting in endothelial dysfunction This ischemia-reperfusion blood flow occlusion and resupply triggered injury can be reduced or prevented by preceding brief periods of ischemia called preconditioning Properly-performed preconditioning can exert a powerful protection against a subsequent sustained period of ischemia in a variety of organs in the body including the heart kidney and skeletal muscle Preconditioning protocol involves repeated brief inflation and deflation of a blood pressure cuff In many of human cardiovascular research studies it is common to measure endothelial function and ambulatory 24-hour blood pressure The ambulatory blood pressure device takes repeated blood pressure readings every 15-30 minutes during the daytime and 30-60 minutes at night It is possible that repeated bouts of inflationdeflation of the blood pressure cuff could induce preconditioning effects and influence endothelial function Therefore in the proposed study we aim to address this hypothesis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None