Ignite Creation Date:
2024-05-05 @ 4:37 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00285844
Status:
COMPLETED
Last Update Posted:
2016-11-04
First Post:
2006-01-31
Brief Title:
Integrating the Genetic and Metabolic Faces of Obesity
Sponsor:
Stanford University
Organization:
Stanford University
Study Overview
Official Title:
Integrating the Genetic and Metabolic Faces of Obesity
Status:
COMPLETED
Status Verified Date:
2016-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to determine why some obese individuals develop insulin resistance and others do not We hypothesize that an impairment in differentiation of fat cells adipocytes is responsible for the development of insulin resistance in select obese individuals This study will evaluate obese individuals at baseline with respect to characteristics of adipocytes including gene expression and will then entail randomizing subjects to either weight loss or treatment with an insulin sensitizing drug pioglitazone Changes in insulin resistance will be associated with changes in adipocyte morphology and gene expression
Detailed Description:
Healthy overweightobese individuals will be screened for insulin resistance Both insulin resistant individuals and insulin sensitive individuals to serve as controls will be eligible to enroll Fat cel biopsy and CT scan of the abdomen is required at baseline and after an intervention with either weight loss or pioglitazone drug to improve insulin resistance Subjects will repeat insulin resistance test after the intervention as well Subjects will learn much about their metabolism in this study and will have an opportunity to improve their insulin resistance
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None