Ignite Creation Date:
2024-05-06 @ 10:36 AM
Last Modification Date:
2024-10-26 @ 12:32 PM
Study NCT ID:
NCT03303378
Status:
UNKNOWN
Last Update Posted:
2017-10-06
First Post:
2017-10-02
Brief Title:
Effects of Melatonin on Reperfusion Injury
Sponsor:
Chinese PLA General Hospital
Organization:
Chinese PLA General Hospital
Study Overview
Official Title:
Effects of Melatonin on Reperfusion Injury in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Status:
UNKNOWN
Status Verified Date:
2017-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Acute myocardial infarction is a major cause of mortality and morbidity Primary percutaneous coronary intervention pPCI is currently the most effective treatment strategy in acute myocardial infarction However a sizable number of patients fail to restore optimal myocardial reperfusion mostly because of the no-reflow phenomenon Melatonin is the chief indoleamine produced by the pineal gland and a well-known antioxidant and free radical scavenger Several studies have shown that melatonin protects against ischemiareperfusion injury IRI In our previous study melatonin markedly reduced infarcted area improved cardiac function and reduced lactate dehydrogenase release in rats The investigators planned to research the cardioprotective effects of intravenous melatonin administered prior to reperfusion and continued after restoration of coronary blood flow in patients with ST segment elevation myocardial infarction undergoing pPCI
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None