Ignite Creation Date:
2024-05-06 @ 10:34 AM
Last Modification Date:
2024-10-26 @ 12:32 PM
Study NCT ID:
NCT03298711
Status:
COMPLETED
Last Update Posted:
2020-10-22
First Post:
2017-09-22
Brief Title:
Central Sensitization and Alteration of Circulating Neurosteroid
Sponsor:
Seoul National University Bundang Hospital
Organization:
Seoul National University Bundang Hospital
Study Overview
Official Title:
Relationship Between Central Sensitization and Alteration of Circulating Neurosteroid Following Bilateral Total Knee Arthroplasty
Status:
COMPLETED
Status Verified Date:
2020-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
For patients who underwent two-stage replacement of both knee joints one knee surgery - one week term- the other knee surgery postoperative pain and analgesic usage with patient-controlled analgesia PCA increased at the second stage which suggests that central sensitization occurs within a short period one week in patients who undergo total knee arthroplasty TKA Neurosteroids act on NMDA and AMPA receptors GABAa receptors and voltage-dependent Ca2 or K channels of sensory neurons to increase invasive or neuropathic pain and conversely to exhibit analgesic and anticonvulsant effects These actions mean that the neurosteroid acts as an endogenous regulator of pain control and central sensitization The purpose of this study is to confirm that the hypothalamus-pituitary-adrenal HPA axis which is the main body of endocrine neurosteroid is associated with increased pain sensitivity after TKA The concentrations of cortisol and dehydroepiandrosterone DHEA in the saliva of patients who undergo two-staged bilateral knee replacement surgery one knee surgery - one week term- the other knee surgery will be measured at each stage and analyzed for correlation between concentration-related changes of HPA and postoperative knee pain variations
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None