Ignite Creation Date:
2024-05-06 @ 10:34 AM
Last Modification Date:
2024-10-26 @ 12:32 PM
Study NCT ID:
NCT03296319
Status:
COMPLETED
Last Update Posted:
2020-12-31
First Post:
2017-08-27
Brief Title:
Echocardiography Guided Fluid Resuscitation in Critically Ill Patients
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Echocardiography Guided Fluid Resuscitation in Critically Ill Patients
Status:
COMPLETED
Status Verified Date:
2020-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To compare between the impact of echocardiography guided fluid resuscitation and clinically guided fluid resuscitation on critically ill patients in hospital outcome
Detailed Description:
Resuscitation often requires the infusion of intravenous fluid in an effort to reverse organ dysfunction The harms of inappropriate use of fluid are becoming increasingly apparent The question of whether the patient improves with fluid additional vasopressors or inotropes can be difficult to answer The gold standard for assessing fluid responsiveness to guide fluid administration in critically ill patients is to perform a fluid challenge The rationale for volume expansion is to increase the cardiac output CO and oxygen delivery to ultimately improve tissue oxygenation This involves the infusion of a specific amount of intravenous fluid to assess ventricular preload reserve and subsequent systemic haemodynamic effects In a patient with acute hemodynamic instability a fluid challenge will cause an increase in stroke volume according to the Frank-Starling curve This increase in stroke volume has a salutary effect because it improves tissue perfusion In contrast higher hydrostatic pressures in the vascular system predispose the patient to edema organic dysfunction and increased risk of in-hospital mortality
Fluid responsiveness is conventionally defined as an increase of at least 10 to 15 in SV in response to a fluid challenge which is a reflection of the limits of precision of the technology used
Assessment of the response in flow to a fluid challenge can be guided with echocardiography It is achieved by measuring left ventricular outflow tract velocity time integral LVOT VTI immediately before and after fluid challenge
Fluid responsiveness is conventionally defined as an increase of at least 10 to 15 in SV in response to a fluid challenge which is a reflection of the limits of precision of the technology used
Assessment of the response in flow to a fluid challenge can be guided with echocardiography It is achieved by measuring left ventricular outflow tract velocity time integral LVOT VTI immediately before and after fluid challenge
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None