Ignite Creation Date:
2024-05-06 @ 10:32 AM
Last Modification Date:
2024-10-26 @ 12:32 PM
Study NCT ID:
NCT03288623
Status:
COMPLETED
Last Update Posted:
2019-04-17
First Post:
2017-09-14
Brief Title:
The Effects of Dark Chocolate Implementation in Elite Athletes
Sponsor:
University of Roma La Sapienza
Organization:
University of Roma La Sapienza
Study Overview
Official Title:
The Effects of Dark Chocolate Implementation in the Reduction of Oxidative Stress and Improvement of Vascular Function and Physical Performance in Elite Athletes
Status:
COMPLETED
Status Verified Date:
2019-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Dark chocolate DC is rich in epicatechin which augments nitric oxide NO production through endothelium-dependent influences The increased bioavailability and activity of NO have been demonstrated to statistically increase flow-mediated dilation in healthy subjects and in hypertensive patients DC supplementation has been hailed for its positive effects on cardiovascular health and it has been proposed as a booster of physical performance in athletes however the mechanisms by which DC improves oxidative stress vascular function and athletic performance are not fully understood The investigators designed a human study assessing how DC improves NO bioavailability and activity in elite athletes Twenty-four elite soccer players aged 18-35 years old all males are divided in 2 groups and randomly assigned to receive DC 85 cocoa 40g per day or whitemilk chocolate 35 cocoa for 30 days The primary outcome measure is the evaluation of Soluble NOX2-derived peptide sNOX2-dp a direct marker of NADPH oxidase activation The secondary outcome measures are other markers of oxidative stress as the soluble P-selectin sPs Vitamin E soluble CD40 Ligand sCD40L a marker of in vivo platelet activation and flow-mediated dilation assessed by vascular ultrasound All parameters are assessed at baseline and after 30 days in both groups
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None