Ignite Creation Date:
2024-05-06 @ 10:26 AM
Last Modification Date:
2024-10-26 @ 12:29 PM
Study NCT ID:
NCT03250637
Status:
COMPLETED
Last Update Posted:
2017-08-15
First Post:
2017-08-11
Brief Title:
Diet Genes and Colorectal Cancer - With Focus on Toll-like Receptor Polymorphisms
Sponsor:
University of Southern Denmark
Organization:
University of Southern Denmark
Study Overview
Official Title:
Meat and Fiber Intake and Interaction With Pattern Recognition Receptors TLR1 TLR2 TLR4 and TLR10 in Relation to Colorectal Cancer in a Danish Prospective Case-cohort Study
Status:
COMPLETED
Status Verified Date:
2017-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to investigate the interaction between diet - primary meat and fiber - and polymorphisms in Toll-like receptors in relation to risk of colorectal cancer in a Danish prospective cohort
Detailed Description:
Meat and dietary fibers have been associated with increased and decreased risk of colorectal cancer CRC respectively Toll-like receptors TLRs regulate intestinal immune response in a complex interplay between the mucosal epithelium and the microbiota and may therefore be important modulators of diet-induced CRC and interact with other inflammatory mediators
The aim of the study is to investigate the association with functional TLR polymorphisms in relation to risk of CRC and their interaction with dietary factors Additionally interactions with previously studied polymorphisms in IL10 IL1B PTGS2 and NFKB1 will be assessed in order to examine possible biological pathways in meat-induced CRC
Data are retrieved from the Danish prospective Diet Cancer and Health study encompassing 57053 persons which were recruited between 1993 to 1997 Between 1994 and 31th December 2009 1038 CRC cases has been diagnosed A sub-cohort of 1857 persons has been randomly selected within the full cohort at time of entry into the cohort The study design is a nested case-cohort study
The aim of the study is to investigate the association with functional TLR polymorphisms in relation to risk of CRC and their interaction with dietary factors Additionally interactions with previously studied polymorphisms in IL10 IL1B PTGS2 and NFKB1 will be assessed in order to examine possible biological pathways in meat-induced CRC
Data are retrieved from the Danish prospective Diet Cancer and Health study encompassing 57053 persons which were recruited between 1993 to 1997 Between 1994 and 31th December 2009 1038 CRC cases has been diagnosed A sub-cohort of 1857 persons has been randomly selected within the full cohort at time of entry into the cohort The study design is a nested case-cohort study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None