Ignite Creation Date:
2024-05-06 @ 10:25 AM
Last Modification Date:
2024-10-26 @ 12:29 PM
Study NCT ID:
NCT03250702
Status:
COMPLETED
Last Update Posted:
2017-08-17
First Post:
2017-08-11
Brief Title:
DUCS-DHD Determinants of Hypertension in Tanzania
Sponsor:
Harvard School of Public Health HSPH
Organization:
Harvard School of Public Health HSPH
Study Overview
Official Title:
Dar es Salaam Urban Cohort Hypertension Study
Status:
COMPLETED
Status Verified Date:
2017-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DUCS-HTN
Brief Summary:
The aim of the Dar es Salaam Urban Cohort Hypertension Study DUCS-HTN was to determine the current prevalence risk factors and barriers to diagnosis and treatment for hypertension in Dar es Salaam Tanzania Few previous studies in Tanzania have analyzed the modifiable determinants of high BP as well as barriers to diagnosis and treatment of hypertension
DUCS-HTN is a cohort of adults living in the Ukonga ward of Dar es Salaam who had been registered in the Dar es Salaam Health and Demographic Surveillance System HDSS in 2011 Due to the large size of Ukonga the investigators chose to randomly sample two of the seven neighborhoods that compose Ukonga and then conducted a census of these two randomly selected neighborhoods Mwembe Madafu and Markazi The investigators attempted to contact all 4896 HDSS participants who were at least 40 years of age and lived in one of these neighborhoods
Trained interviewers conducted face-to-face interviews and physical examinations in participants homes from March to June 2014 Follow-up visits were conducted from April to June 2015
Among 4896 potentially eligible participants from the HDSS baseline survey 3604 74 were still living at the same address in 2014 Of these 2290 64 enrolled in the DUCS-HTN study Of the participants enrolled at baseline 1752 77 participated in the follow-up study
Blood pressure measurements
Trained interviewers measured blood pressure with digital blood pressure monitors 15 Omron M2 and 5 Beurer BM 40 monitors Standard large and extra-large cuff sizes were used according to the size of a participants arm Blood pressure was measured three times with at least a 5-minute rest before the first measurement and 3-minute rests between each subsequent measurement Blood pressure was taken on the left arm with the participant seated and the arm straight at heart level Usual blood pressure values were calculated as the mean of the second and third readings If a second visit was conducted usual blood pressure values were defined as the mean of the second and third readings at both the first and second visits
Hypertension was defined as SBP140 mmHg or DBP90 mmHg or self-reported use of anti-hypertensive medication Grade I hypertension was defined as SBP of 140 to 159 or DBP of 90 to 99 mmHg grade II hypertension was defined as SBP of 160 to 179 or DBP of 100 to 109 mmHg and grade III hypertension was defined as SBP180 or DBP110 mmHg Hypertension control was defined as current antihypertensive use and blood pressure of less than 14090 mmHg If a participant was found to have grade I or II hypertension a second visit was scheduled at least three days later Those with grade III hypertension at the last reading of the first visit or grade I or II hypertension at the last reading of the second visit were told that they had high blood pressure advised to see a health professional and were given a referral letter In addition a second visit and blood pressure reading was scheduled for a random sample of one-fifth of participants who were selected for additional blood urinary and dietary measurements
Assessment of covariates
All participants were administered a socio-demographic and lifestyle questionnaire and had their height weight and waist and hip circumference measured Some demographic information age sex neighborhood religion and assets used to create a household wealth index was previously recorded during the HDSS baseline Information on household health insurance coverage was collected in 2015 as part of routine HDSS updates
Standard protocols were used to take anthropometric measurements Participants were weighed with minimal clothing using a digital scale Seca Germany to the nearest 01kg and height was measured with participants not wearing shoes to the nearest 1cm Body mass index BMI was calculated as the ratio of weight in kilograms to height in meters squared kgm2 and categorized according to WHO categories
The Global Physical Activity Questionnaire GPAQ was used to assess physical activity for work transportation and leisure The investigators defined physical inactivity according to WHO guidelines Number of servings of alcoholic beverages consumed was reported over the past 30 days The investigators assumed 14 grams of alcohol as a standard drink portion size A household wealth index was created through a principal component analysis of household characteristics and assets and was categorized into quintiles In the follow-up visit participants were asked about their health over the past year and the reasons for not seeking hypertension care
A subsample of one fifth of the participants completed a food frequency questionnaire two 24-hour dietary recalls a 24-hour urine collection for sodium creatinine protein and potassium and had capillary total cholesterol and blood glucose measurements taken
DUCS-HTN is a cohort of adults living in the Ukonga ward of Dar es Salaam who had been registered in the Dar es Salaam Health and Demographic Surveillance System HDSS in 2011 Due to the large size of Ukonga the investigators chose to randomly sample two of the seven neighborhoods that compose Ukonga and then conducted a census of these two randomly selected neighborhoods Mwembe Madafu and Markazi The investigators attempted to contact all 4896 HDSS participants who were at least 40 years of age and lived in one of these neighborhoods
Trained interviewers conducted face-to-face interviews and physical examinations in participants homes from March to June 2014 Follow-up visits were conducted from April to June 2015
Among 4896 potentially eligible participants from the HDSS baseline survey 3604 74 were still living at the same address in 2014 Of these 2290 64 enrolled in the DUCS-HTN study Of the participants enrolled at baseline 1752 77 participated in the follow-up study
Blood pressure measurements
Trained interviewers measured blood pressure with digital blood pressure monitors 15 Omron M2 and 5 Beurer BM 40 monitors Standard large and extra-large cuff sizes were used according to the size of a participants arm Blood pressure was measured three times with at least a 5-minute rest before the first measurement and 3-minute rests between each subsequent measurement Blood pressure was taken on the left arm with the participant seated and the arm straight at heart level Usual blood pressure values were calculated as the mean of the second and third readings If a second visit was conducted usual blood pressure values were defined as the mean of the second and third readings at both the first and second visits
Hypertension was defined as SBP140 mmHg or DBP90 mmHg or self-reported use of anti-hypertensive medication Grade I hypertension was defined as SBP of 140 to 159 or DBP of 90 to 99 mmHg grade II hypertension was defined as SBP of 160 to 179 or DBP of 100 to 109 mmHg and grade III hypertension was defined as SBP180 or DBP110 mmHg Hypertension control was defined as current antihypertensive use and blood pressure of less than 14090 mmHg If a participant was found to have grade I or II hypertension a second visit was scheduled at least three days later Those with grade III hypertension at the last reading of the first visit or grade I or II hypertension at the last reading of the second visit were told that they had high blood pressure advised to see a health professional and were given a referral letter In addition a second visit and blood pressure reading was scheduled for a random sample of one-fifth of participants who were selected for additional blood urinary and dietary measurements
Assessment of covariates
All participants were administered a socio-demographic and lifestyle questionnaire and had their height weight and waist and hip circumference measured Some demographic information age sex neighborhood religion and assets used to create a household wealth index was previously recorded during the HDSS baseline Information on household health insurance coverage was collected in 2015 as part of routine HDSS updates
Standard protocols were used to take anthropometric measurements Participants were weighed with minimal clothing using a digital scale Seca Germany to the nearest 01kg and height was measured with participants not wearing shoes to the nearest 1cm Body mass index BMI was calculated as the ratio of weight in kilograms to height in meters squared kgm2 and categorized according to WHO categories
The Global Physical Activity Questionnaire GPAQ was used to assess physical activity for work transportation and leisure The investigators defined physical inactivity according to WHO guidelines Number of servings of alcoholic beverages consumed was reported over the past 30 days The investigators assumed 14 grams of alcohol as a standard drink portion size A household wealth index was created through a principal component analysis of household characteristics and assets and was categorized into quintiles In the follow-up visit participants were asked about their health over the past year and the reasons for not seeking hypertension care
A subsample of one fifth of the participants completed a food frequency questionnaire two 24-hour dietary recalls a 24-hour urine collection for sodium creatinine protein and potassium and had capillary total cholesterol and blood glucose measurements taken
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None