Ignite Creation Date:
2024-05-06 @ 10:24 AM
Last Modification Date:
2024-10-26 @ 12:29 PM
Study NCT ID:
NCT03250819
Status:
COMPLETED
Last Update Posted:
2020-06-01
First Post:
2017-08-11
Brief Title:
Gene Polymorphisms of Corticosteroid-induced Ocular Hypertension
Sponsor:
Maastricht University Medical Center
Organization:
Maastricht University Medical Center
Study Overview
Official Title:
Genetic Association Study on Corticosteroid-induced Elevation of the Intraocular Pressure
Status:
COMPLETED
Status Verified Date:
2020-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Glaucoma is one of the most prevalent eye diseases and the second most common cause of blindness worldwide The most common form is primary open angle glaucoma POAG Glaucoma is a slowly progressing neuropathy of the optic nerve that causes loss of visual field and eventually blindness Elevated intra-ocular pressure IOP is the most important risk factor
Corticosteroids which are often used for the treatment of many diseases in ophthalmology and other specialities may cause an elevation of the IOP It is estimated that corticosteroids induce ocular hypertension in approximately 18-36 of the general population and in patients with POAG this percentage can be as high as 92 When the treatment is sustained this can cause a glaucomatous neuropathy of the optic nerve corticosteroid-induced glaucoma
The precise pathogenic mechanism isnt clear yet Genetic factors are likely to affect the susceptibility to corticosteroid response Therefore an overview of the genetic mechanisms of corticosteroid-induced glaucoma can give more insight in the pathogenesis In this study the researchers investigate the occurrence of SNPs single nucleotide polymorphisms in 150 cases with a steroid-response in comparison with 300 controls exposed to corticosteroids without a steroid-response
Up to now one small GWAS has been conducted comparing 32 patients with and without corticosteroid-induced ocular hypertension after treatment with intravitreal triamcinolone In this study two SNPs proximal of the transcriptional start site near the 5 of HCG22 on chromosome 6 were identified However this is a rather small sample population and the investigators didnt match for the underlying disease Further in another small study Hogewind et al performed SNP analysis in multiple genes SFRS3 FKBP4 FKBP5 and NR3C1 in corticosteroid-induced ocular hypertension
This study enables the investigators to identify patients at risk for developing corticosteroid-induced glaucoma and to gain a better insight in the pathogenesis This may also lead to the discovery of biomarkers that indicate an increased risk of developing a steroid-induced glaucoma and new prevention and treatment strategies which are necessary as the treatment of corticosteroid induced-glaucoma now only focuses at lowering the IOP and can still be challenging
Corticosteroids which are often used for the treatment of many diseases in ophthalmology and other specialities may cause an elevation of the IOP It is estimated that corticosteroids induce ocular hypertension in approximately 18-36 of the general population and in patients with POAG this percentage can be as high as 92 When the treatment is sustained this can cause a glaucomatous neuropathy of the optic nerve corticosteroid-induced glaucoma
The precise pathogenic mechanism isnt clear yet Genetic factors are likely to affect the susceptibility to corticosteroid response Therefore an overview of the genetic mechanisms of corticosteroid-induced glaucoma can give more insight in the pathogenesis In this study the researchers investigate the occurrence of SNPs single nucleotide polymorphisms in 150 cases with a steroid-response in comparison with 300 controls exposed to corticosteroids without a steroid-response
Up to now one small GWAS has been conducted comparing 32 patients with and without corticosteroid-induced ocular hypertension after treatment with intravitreal triamcinolone In this study two SNPs proximal of the transcriptional start site near the 5 of HCG22 on chromosome 6 were identified However this is a rather small sample population and the investigators didnt match for the underlying disease Further in another small study Hogewind et al performed SNP analysis in multiple genes SFRS3 FKBP4 FKBP5 and NR3C1 in corticosteroid-induced ocular hypertension
This study enables the investigators to identify patients at risk for developing corticosteroid-induced glaucoma and to gain a better insight in the pathogenesis This may also lead to the discovery of biomarkers that indicate an increased risk of developing a steroid-induced glaucoma and new prevention and treatment strategies which are necessary as the treatment of corticosteroid induced-glaucoma now only focuses at lowering the IOP and can still be challenging
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None