Ignite Creation Date:
2024-05-05 @ 4:36 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00276133
Status:
COMPLETED
Last Update Posted:
2007-05-09
First Post:
2006-01-11
Brief Title:
Effects of Atorvastatin Versus Probucol on Small Dense LDL
Sponsor:
Yokohama City University Medical Center
Organization:
Yokohama City University Medical Center
Study Overview
Official Title:
Effects of Atorvastatin Versus Probucol on Low-Density Lipoprotein Subtype Distribution and Renal Function in Hyperlipidemic Patients With Non-Diabetic Nephropathy
Status:
COMPLETED
Status Verified Date:
2007-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Small dense low-density lipoprotein LDL plays an important role in causing glomerular injury through conversion to an oxidatively modified form of LDL However few studies evaluated the effects of antilipidemic agents on the LDL particle size and renoprotective actions in hyperlipidemic patients with non-diabetic nephropathy
Detailed Description:
The study is a randomized crossover trial comparing the effect of atorvastatin 10 mgday and probucol 500 mgday for 24 weeks in 30 patients urinary albumin excretion 03-20 gday and creatinine clearance 30 mlmin173 m2 or serum creatinine concentration 2 mgL Lipid parameters mean LDL particle diameter creatinine clearance and urinary albumin to creatinine excretion ratio are measured before and during treatment periods It will be evaluated that first whether atorvastatin and probucol significantly reduce serum total cholesterol and LDL cholesterol concentrations second whether atorvastatin and probucol significantly increase the LDL particle size third whether significant differences in urinary albumincreatinine excretion ratio and creatinine clearance are observed in both groups during treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None