Ignite Creation Date:
2024-05-06 @ 10:19 AM
Last Modification Date:
2024-10-26 @ 12:28 PM
Study NCT ID:
NCT03220438
Status:
TERMINATED
Last Update Posted:
2021-09-02
First Post:
2017-07-14
Brief Title:
TMS Enhancement of Visual Plasticity in Schizophrenia
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Testing TMS Enhancement of Visual Plasticity in Schizophrenia
Status:
TERMINATED
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Principal Investigator took another position elsewhere
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The major goal is to determine if Transcranial magnetic stimulation TMS enhances visual plasticity in schizophrenia TMS sessions shamplacebo and real TMS will be conducted before two MRI scans with two weeks in-between to assess whether TMS stimulation to the visual cortex will enhance visual plasticity in patients with schizophrenia-spectrum disorders This project may provide a better understanding of the underlying neurobiological mechanisms responsible for learning and memory deficits in schizophrenia
Detailed Description:
Learning and memory impairments are commonly observed in schizophrenia spectrum disorders Alterations in long-term potentiation LTP a basic mechanism underlying learning and memory may explain this impairment This project will assess fMRI visual plasticity thought to reflect LTP in participants with and without schizophrenia spectrum disorders Previous studies have shown that visual plasticity is impaired in schizophrenia The major goal is to determine if Transcranial magnetic stimulation TMS enhances visual plasticity in schizophrenia Transcranial magnetic stimulation TMS provides a non-invasive means for altering brain electrical neural activity TMS sessions shamplacebo and real TMS will be conducted before two MRI scans with two weeks in-between to assess whether TMS stimulation to the visual cortex will enhance visual plasticity in patients with schizophrenia-spectrum disorders This project may provide a better understanding of the underlying neurobiological mechanisms responsible for learning and memory deficits in schizophrenia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None