Ignite Creation Date:
2024-05-06 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 12:27 PM
Study NCT ID:
NCT03211923
Status:
UNKNOWN
Last Update Posted:
2019-10-01
First Post:
2017-06-28
Brief Title:
Muscle Relaxation in Myopathies With Positive Muscle Phenomena
Sponsor:
Radboud University Medical Center
Organization:
Radboud University Medical Center
Study Overview
Official Title:
Muscle Relaxation Properties in Myopathies With Positive Muscle Phenomena a Study Using Transcranial Magnetic Stimulation
Status:
UNKNOWN
Status Verified Date:
2018-09
Last Known Status:
ENROLLING_BY_INVITATION
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to quantify muscle relaxation properties of the finger flexor muscles in patients with different myopathies The inhibiting effects of transcranial magnetic stimulation TMS on the cortical motor hand area are used to induce relaxation which in turn will be monitored with handgrip dynamometry and EMG The investigators will evaluate if this technique can be implemented as a diagnostic tool in clinical practice
Muscle relaxation is an often overlooked property of the muscle as compared to muscle strength or activation Muscle relaxation is affected in different myopathies such as myotonic dystrophy non-dystrophic myotonias and Brody myopathy Therefore a diagnostic tool to quantify muscle relaxation is of clinical and scientific importance In this study transcranial magnetic stimulation TMS is used in combination with a dynamometer to quantify muscle relaxation properties
Transcranial magnetic stimulation TMS is a non-invasive technique that is commonly used to stimulate the brain In practice a circular coil is held directly above the scalp upon which a strong current pulse induces a magnetic field that stimulates the underlying superficial brain areas This stimulation can have both activating and inhibiting effects
When the motor cortex ie the area of the brain that controls muscle contractions is strongly stimulated with TMS during a voluntary muscle contraction both excitatory and inhibitory effects can be observed in the muscle the targeted cortical area controls The inhibitory effect entails a transient interruption of neural drive to the muscle This interruption called the silent period lasts for less than half a second and results in the relaxation of the muscle Muscle activity and control quickly return to normal after the silent period
The elegance and main advantage of TMS-induced muscle relaxation lies in the fact that it excludes all voluntary influences on the relaxation process Furthermore the TMS pulse causes all muscle fibres involved in the contraction just prior to the onset of the silent period to relax simultaneously This allows us to study muscle relaxation as only a property of the muscle ie without voluntary influences
In this study the investigators will measure muscle relaxation in several myopathies McArdle disease Nemaline myopathy type 6 and myotonic dystrophy type 2 and compare this to healthy controls and to controls with no myopathy but with similar complaints myalgia stiffness cramps The data from these two control groups has been gathered previously in a different study The investigators will also compare this to patients suffering from Brody disease who were previously measured in a different study
Muscle relaxation will be evaluated in fresh and fatigued finger flexor muscles The main outcome of this study is the peak relaxation rate normalized to the peak force preceding relaxation
The final outlook of this research is to evaluate whether muscle relaxation studied with TMS can be used for different myopathies as a diagnostic tool to monitor disease progression and to study the effects of different interventions eg medication exercise
Muscle relaxation is an often overlooked property of the muscle as compared to muscle strength or activation Muscle relaxation is affected in different myopathies such as myotonic dystrophy non-dystrophic myotonias and Brody myopathy Therefore a diagnostic tool to quantify muscle relaxation is of clinical and scientific importance In this study transcranial magnetic stimulation TMS is used in combination with a dynamometer to quantify muscle relaxation properties
Transcranial magnetic stimulation TMS is a non-invasive technique that is commonly used to stimulate the brain In practice a circular coil is held directly above the scalp upon which a strong current pulse induces a magnetic field that stimulates the underlying superficial brain areas This stimulation can have both activating and inhibiting effects
When the motor cortex ie the area of the brain that controls muscle contractions is strongly stimulated with TMS during a voluntary muscle contraction both excitatory and inhibitory effects can be observed in the muscle the targeted cortical area controls The inhibitory effect entails a transient interruption of neural drive to the muscle This interruption called the silent period lasts for less than half a second and results in the relaxation of the muscle Muscle activity and control quickly return to normal after the silent period
The elegance and main advantage of TMS-induced muscle relaxation lies in the fact that it excludes all voluntary influences on the relaxation process Furthermore the TMS pulse causes all muscle fibres involved in the contraction just prior to the onset of the silent period to relax simultaneously This allows us to study muscle relaxation as only a property of the muscle ie without voluntary influences
In this study the investigators will measure muscle relaxation in several myopathies McArdle disease Nemaline myopathy type 6 and myotonic dystrophy type 2 and compare this to healthy controls and to controls with no myopathy but with similar complaints myalgia stiffness cramps The data from these two control groups has been gathered previously in a different study The investigators will also compare this to patients suffering from Brody disease who were previously measured in a different study
Muscle relaxation will be evaluated in fresh and fatigued finger flexor muscles The main outcome of this study is the peak relaxation rate normalized to the peak force preceding relaxation
The final outlook of this research is to evaluate whether muscle relaxation studied with TMS can be used for different myopathies as a diagnostic tool to monitor disease progression and to study the effects of different interventions eg medication exercise
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None