Ignite Creation Date:
2025-12-24 @ 4:19 PM
Ignite Modification Date:
2026-01-01 @ 6:02 PM
Study NCT ID:
NCT07010666
Status:
COMPLETED
Last Update Posted:
2025-06-08
First Post:
2025-05-13
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
BHB and Cognition During Exercise-Heat Stress
Sponsor:
University of South Carolina
Organization:
Study Overview
Official Title:
Beta-Hydroxybutyrate Ingestion and Cognition During Exercise-Heat Stress
Status:
COMPLETED
Status Verified Date:
2025-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study investigates how consuming a ketone ester (BHB) along with caffeine impacts cognitive performance under heat stress, similar to what military personnel experience in hot environments. The extreme heat can impair brain function, affecting decision-making and performance, which is critical for Special Operations Forces (SOF). BHB provides an alternative energy source for the brain, potentially improving brain blood flow and cognition, particularly during "stressful" situations. By comparing ketone and carbohydrate intake with caffeine, this study aims to find better ways to maintain mental sharpness during stressful conditions. The results could help enhance the safety and effectiveness of military operations.
Detailed Description:
This study aims to examine the effects of ingestion of 25g of BHB ketone ester and 4 mg/kg of caffeine on cognitive performance during exercise-heat induced hyperthermia when compared to carbohydrate combined with the same dosage of caffeine. This will be the first study to investigate the effects of ketone ester ingestion on cognition during exercise-heat induced hyperthermia in endurance-trained adults. Further, this study has the potential to impact the safety and mission success of SOF by improving cognitive performance when making critical decisions in a physiologically compromised state.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?: