Ignite Creation Date:
2024-05-05 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 9:22 AM
Study NCT ID:
NCT00272896
Status:
COMPLETED
Last Update Posted:
2006-01-09
First Post:
2006-01-04
Brief Title:
Hemodynamic and Headache-Inducing Effect of Intravenous Vasoactive Intestinal Peptide in Migraineurs
Sponsor:
Danish Headache Center
Organization:
Danish Headache Center
Study Overview
Official Title:
Hemodynamic and Headache-Inducing Effect of Intravenous Vasoactive Intestinal Peptide VIP in Migraineurs
Status:
COMPLETED
Status Verified Date:
2004-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We hypothesized that infusion of VIP may induce headachemigraine in migraineurs and that VIP-induced headache may be associated with dilation of intra- and extracranial vessels To test this hypothesis we performed a double blind placebo-controlled crossover study in migraineurs and studied the effect on headache and cerebral and systemic hemodynamic parameters
Detailed Description:
We hypothesized that infusion of VIP may induce headachemigraine in migraineurs and that VIP-induced headache may be associated with dilation of intra- and extracranial vessels To test this hypothesis we performed a double blind placebo-controlled crossover study in migraineurs and studied the effect on headache and cerebral and systemic hemodynamic parameters The subjects were randomly allocated to the infusion of 8pmolkgmin VIP or placebo isotonic saline duration 25min Headache intensity mean velocity of blood flow in the middle cerebral artery VmMCA superficial temporal artery diameter end-expiratory CO2 and vital signs were recorded at baseline and then every 10 min until 120 min after start of the infusion The patients received a headache diary for the following 12 hours after infusion
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None