Ignite Creation Date:
2024-05-05 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00270608
Status:
UNKNOWN
Last Update Posted:
2007-11-27
First Post:
2005-12-26
Brief Title:
How Does Early Age Life Style Affect Bone Strength and General Health Parameters at Middle Age
Sponsor:
Hadassah Medical Organization
Organization:
Hadassah Medical Organization
Study Overview
Official Title:
How Does Early Age Life Style Affect Bone Strength and General Health at Middle Age Twenty-Five Year Follow-up Health Status Comparison of a Sedentary Versus Extremely Physically Active Population From an Early Age
Status:
UNKNOWN
Status Verified Date:
2007-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to evaluate the effect of vigorous physical activity versus extremely sedentary life style during young age on the bone mineral density and general health in later life
Detailed Description:
Bone strength and peak bone mass are preliminary determined by genetic factors Life style especially exercise is also considered to have an important effect on bone strength Bone has the ability to strengthen itself according to Wolffs Law When bone is subjected to strains andor strain rates higher than the usual it responds by remodeling strengthening its architecture The ability is greatest in young individuals and decreases with age In the elderly this ability is largely non-existent and bone mass is lost Whether this loss leads to osteoporosis is largely a function of the peak bone mass achieved before the decline 11 of males and 44 of females over 50 suffer from osteoporosis in later life To what extent vigorous exercising beginning at a young age can increase bone strength is not known
The purpose of the proposed research is to quantify the effect of life style on bone strength and general health parameters by comparing two male populations one sedentary and the other that has done demanding physical training 1 Elite infantry recruits who were inducted into the IDF in Feb 1983 did their basic training at Sanur and were part of the 1983 stress fracture project who completed three years of elite infantry service and continued to serve as combat soldiers in the reserves 2 Yeshiva students who had profiles of 82 or 97 and received deferment from their military service in 1983 and since then have continued their studies and never served in the army
50 subjects will be reviewed in each group Measurements of weight height waist and abdominal girth resting pulse and blood pressure will be made The brachialankle blood pressure index will be recorded MRI of the right knee to study potential degenerate changes will be done using a 15 Tesla General Electric Signa MR scanner Quantitative Computed Tomography QCT one of the most popular and effective methods utilized for osteoporosis screening will be performed to determine volumetric BMD BMC bone geometric properties and strength indexes of the tibia and lumbar spine
Comparisons
Group I 50 males age 41-45 former elite Israeli infantry soldiers selected randomly from those recruits who did their infantry basic training at Sanur in Feb 1983 all profiled 82 or 97 and completed their military service as combat soldiers will be compared to
Group II 50 age- profile- and ethnically-matched Israeli citizens whose military service was deferred in 1983 because of Torah studies and who did not do army service and were not involved in any kind of physical training
The purpose of the proposed research is to quantify the effect of life style on bone strength and general health parameters by comparing two male populations one sedentary and the other that has done demanding physical training 1 Elite infantry recruits who were inducted into the IDF in Feb 1983 did their basic training at Sanur and were part of the 1983 stress fracture project who completed three years of elite infantry service and continued to serve as combat soldiers in the reserves 2 Yeshiva students who had profiles of 82 or 97 and received deferment from their military service in 1983 and since then have continued their studies and never served in the army
50 subjects will be reviewed in each group Measurements of weight height waist and abdominal girth resting pulse and blood pressure will be made The brachialankle blood pressure index will be recorded MRI of the right knee to study potential degenerate changes will be done using a 15 Tesla General Electric Signa MR scanner Quantitative Computed Tomography QCT one of the most popular and effective methods utilized for osteoporosis screening will be performed to determine volumetric BMD BMC bone geometric properties and strength indexes of the tibia and lumbar spine
Comparisons
Group I 50 males age 41-45 former elite Israeli infantry soldiers selected randomly from those recruits who did their infantry basic training at Sanur in Feb 1983 all profiled 82 or 97 and completed their military service as combat soldiers will be compared to
Group II 50 age- profile- and ethnically-matched Israeli citizens whose military service was deferred in 1983 because of Torah studies and who did not do army service and were not involved in any kind of physical training
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None