Ignite Creation Date:
2024-05-06 @ 10:12 AM
Last Modification Date:
2024-10-26 @ 12:26 PM
Study NCT ID:
NCT03191175
Status:
COMPLETED
Last Update Posted:
2018-09-28
First Post:
2017-06-14
Brief Title:
Inflammasome Activation Via Circulating Metabolites
Sponsor:
University Hospital Bordeaux
Organization:
University Hospital Bordeaux
Study Overview
Official Title:
Residual Immune Activation in HIV-infected Patients on Successful cART Association Between Inflammasome Activation in Monocytes by Circulating Metabolites and Non AIDS Defining Comorbidities
Status:
COMPLETED
Status Verified Date:
2018-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
InflammoVIH
Brief Summary:
The clinical challenges confronting patients with HIV has shifted over the past 10 years from acquired immunodeficiency syndrome to chronic diseases including atherosclerosis neurocognitive disorders and osteoporosis Chronic low grade inflammation and monocyte activation have been consistently associated with comorbidities in HIV patients Indeed recent studies indicate that inflammatory mediators including IL-6 IL-1 sCD14 and s CD163 produced by monocytes but not T-cell activation predict Non-AIDS-related events in virologically suppressed HIV-infected persons treated with combined antiretroviral therapy cART highlighting the important role of monocyte activation in the occurrence of comorbidities in cART-treated HIV infected patients Yet the underlying molecular pathways of persistent monocyte activation in cART treated HIV-infected patients remains incompletely characterized Our preliminary results 1 establish a link between the activation of the inflammasome the increased of pyrimidine-derived metabolites and the cardiovascular risk in a cohort of elderly patients 2 show that treated HIV-patients are characterized by increased soluble IL-1b or IL-18 in their blood suggesting that the inflammasome pathway is activated
Objectives In this study we will characterize the molecular pathways underlying persistent monocyte activation in treated HIV patients through the implication of the activation of the inflammasome machinery 1 Characterization of NOD like Receptor NLR expression in monocytes for IL-1b and IL-18 secretion inflammasome activation 2 Characterization of circulating metabolites that active the inflammasome machinery 3 Evaluation of the link between the activation of the inflammasome the increased of circulating metabolites and the non-AIDS related comorbidities
Objectives In this study we will characterize the molecular pathways underlying persistent monocyte activation in treated HIV patients through the implication of the activation of the inflammasome machinery 1 Characterization of NOD like Receptor NLR expression in monocytes for IL-1b and IL-18 secretion inflammasome activation 2 Characterization of circulating metabolites that active the inflammasome machinery 3 Evaluation of the link between the activation of the inflammasome the increased of circulating metabolites and the non-AIDS related comorbidities
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None