Ignite Creation Date:
2024-05-05 @ 4:35 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00260871
Status:
UNKNOWN
Last Update Posted:
2011-07-29
First Post:
2005-12-01
Brief Title:
Genetic Epidemiological Study of Lung Cancer in Taiwan and Clinical Applications
Sponsor:
National Health Research Institutes Taiwan
Organization:
National Health Research Institutes Taiwan
Study Overview
Official Title:
Genetic Epidemiological Study of Lung Cancer in Taiwan and Clinical Applications-focusing on Female Lung Adenocarcinoma GEFLAC
Status:
UNKNOWN
Status Verified Date:
2011-07
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Lung adenocarcinoma in Chinese females is hypothesized to be determined by both genetic and environmental factors In this grant proposal we propose to map the loci of susceptibility genes of female lung adenocarcinoma based on multiplex families recruited in Taiwan We focus on a unique pathological type of a unique population in order to reduce heterogeneity of the genetic background Compared with western women female Chinese population has a high prevalence of lung adenocarcinoma Our reasoning is that if we focus on a specific sub-type which has a familial basis we will increase the probability of identifying genes associated with female lung adenocarcinoma The primary goal of this study is to identify the genetic and environmental determinants of female lung adenocarcinoma and study the relationship between gene polymorphisms and clinical manifestation profiling of lung cancer
Detailed Description:
This research proposal intends to integrate epidemiologists biostatisticians clinicians molecular biologistsgeneticists to identify susceptible genes for lung cancer especially for female lung adenocarcinoma and to study the relationship between gene polymorphisms and clinical outcomes of lung cancer patients Our objective is to find gene markers for developing useful screening tools for the high risk group in order to prevent or early detect lung cancer especially female lung adenocarcinoma
The specific aims of this subproject include
1 Establish and maintain the research network that will recruit and follow up the subjects and families for the GEFLAC study keeping control of the progress of the study
2 Coordinate all the subprojects such as integrating genotyping data with clinical data and environment data
3 Continue to employ the candidate gene approach to examine the contribution of specific genes to the lung cancer
4 Generate genotyping data for candidate genes in the exploring stage and prioritize SNPs of candidate genes for large scale studies
5 Identify susceptible genescandidate genes to develop multiplex PCR for screening
The specific aims of this subproject include
1 Establish and maintain the research network that will recruit and follow up the subjects and families for the GEFLAC study keeping control of the progress of the study
2 Coordinate all the subprojects such as integrating genotyping data with clinical data and environment data
3 Continue to employ the candidate gene approach to examine the contribution of specific genes to the lung cancer
4 Generate genotyping data for candidate genes in the exploring stage and prioritize SNPs of candidate genes for large scale studies
5 Identify susceptible genescandidate genes to develop multiplex PCR for screening
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2DOH-94-TD-G-111-027 | None | None | None |
| 1DOH-94-TD-G-111-025 | None | None | None |