Ignite Creation Date:
2024-05-06 @ 10:09 AM
Last Modification Date:
2024-10-26 @ 12:25 PM
Study NCT ID:
NCT03170830
Status:
UNKNOWN
Last Update Posted:
2017-05-31
First Post:
2017-05-19
Brief Title:
Diagnostic Value of CircRNA-Uck2 for Acute Myocardial Infarction
Sponsor:
Beijing Haidian Hospital
Organization:
Beijing Haidian Hospital
Study Overview
Official Title:
Study on CircRNA-Uck2 as a New Diagnostic Marker of Acute Myocardial Infarction
Status:
UNKNOWN
Status Verified Date:
2017-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is an observational diagnostic study that aims to evaluate the diagnostic value of circRNA-Uck2 in Acute Myocardial Infarction AMI in adults as compared to healthy and unstable angina controls Rapid and adequate diagnosis of AMI is of great importance to enable a rapid start of treatment save large tracts of dying myocardium reduce the infarct sizeand thereby decrease the risk of subsequent heart failure
Detailed Description:
RATIONAL acute myocardial infarction AMI is the leading cause of sudden death and heart failure worldwide And about 10 of all emergency department consultations are with symptoms suggestive of AMI however only 10 to 20 of them are diagnosed as experiencing an AMI Rapid and accurate identification of AMI is of paramount clinical importance for subsequent timely and effectively treatment and management
Recently the investigators identified microarray analysis and real-time polymerase chain reaction PCR from AMI animal models and small samples of AMI patients a molecular signature of AMI involving 5 circRNAs circRNA_006877 circRNA_015350 circRNA_002969 circRNA_013240 circRNA_004682 was found significantly change in AMI patients and likely serves as candidate serum biomarkers of AMI Among the 5 circRNAs circRNA_006877 name of circRNA-Uck2 cUck2 has more close association with AMI
TYPE OF STUDY multicenter diagnostic evaluation Study MAIN PURPOSE OF THE STUDY To evaluate the diagnostic value of circRNAs in AMI in adults as compared to healthy and unstable angina controls
SECONDARY OBJECTIVES
assess the ability of cUck2 to discriminate a AMI disease from unstable angina patients in adults
explore the relationship between cUck2 and heart function after myocardial infarction PRODUCTS OF THE STUDY diagnostic kit of AMI in quantitative polymerase chain reaction qPCR NUMBER OF PATIENTS 3 groups with 169 patients will be included Group 1 66 AMI adult patients Group 2 56 unstable angina adults Group 3 56 Witnesses healthy adults INCLUSION LENGTH 36 months DURATION OF THE STUDY 42 months
Recently the investigators identified microarray analysis and real-time polymerase chain reaction PCR from AMI animal models and small samples of AMI patients a molecular signature of AMI involving 5 circRNAs circRNA_006877 circRNA_015350 circRNA_002969 circRNA_013240 circRNA_004682 was found significantly change in AMI patients and likely serves as candidate serum biomarkers of AMI Among the 5 circRNAs circRNA_006877 name of circRNA-Uck2 cUck2 has more close association with AMI
TYPE OF STUDY multicenter diagnostic evaluation Study MAIN PURPOSE OF THE STUDY To evaluate the diagnostic value of circRNAs in AMI in adults as compared to healthy and unstable angina controls
SECONDARY OBJECTIVES
assess the ability of cUck2 to discriminate a AMI disease from unstable angina patients in adults
explore the relationship between cUck2 and heart function after myocardial infarction PRODUCTS OF THE STUDY diagnostic kit of AMI in quantitative polymerase chain reaction qPCR NUMBER OF PATIENTS 3 groups with 169 patients will be included Group 1 66 AMI adult patients Group 2 56 unstable angina adults Group 3 56 Witnesses healthy adults INCLUSION LENGTH 36 months DURATION OF THE STUDY 42 months
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None