Ignite Creation Date:
2024-05-06 @ 10:09 AM
Last Modification Date:
2024-10-26 @ 12:25 PM
Study NCT ID:
NCT03175393
Status:
UNKNOWN
Last Update Posted:
2017-06-05
First Post:
2017-05-31
Brief Title:
Relation Between Postprandial Lipogram and Coronary Artery Disease Severity
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Relation Between Postprandial Lipogram and Coronary Artery Disease Severity
Status:
UNKNOWN
Status Verified Date:
2017-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Coronary artery disease CAD is usually used to refer to the pathological problem affecting the coronary arteries usually atherosclerosis that leads to Coronary Heart disease CHD which includes the diagnoses of angina pectoris MI and silent myocardial ischemia
Despite the mortality for this condition has gradually declined over the last decades in western countries it still causes about one-third of all deaths in people older than 35 years
Dyslipidemia is very important risk factors of atherosclerosis that is one of the causes leading to cardiovascular disease Despite management of dyslipidemia by controling fasting total plasma cholesterol and LDL cholesterol as these are the best biomarkers for prediction of cardiovascular diseases CVD risk
LDL elevation is absent in many patients with atherosclerosis and about 13 of cardiac events remains to be unpredicted using this method Even more in fasting normolipidemic subjects increased CVD risk is associated with an exaggerated postprandial lipemic response
Postprandial dyslipidemia is defined as a rise in triglyceride-rich lipoproteins TRLs including chylomicron remnants CMRs and remnant lipoproteins RLPs after eating has drawn an increasing interest recently because of its association with cardiovascular events Chylomicron remnants CMRs have been shown to penetrate the artery wall and to be retained within the intima
Endothelial dysfunction is an initial process of atherogenesis and it contributes to the pathogenesis of CHD Postprandial hyperlipidemia postprandial hypertriglyceridemia is involved in the production of proinflammatory cytokines recruitment of neutrophils and generation of oxidative stress resulting in endothelial dysfunction
Despite the mortality for this condition has gradually declined over the last decades in western countries it still causes about one-third of all deaths in people older than 35 years
Dyslipidemia is very important risk factors of atherosclerosis that is one of the causes leading to cardiovascular disease Despite management of dyslipidemia by controling fasting total plasma cholesterol and LDL cholesterol as these are the best biomarkers for prediction of cardiovascular diseases CVD risk
LDL elevation is absent in many patients with atherosclerosis and about 13 of cardiac events remains to be unpredicted using this method Even more in fasting normolipidemic subjects increased CVD risk is associated with an exaggerated postprandial lipemic response
Postprandial dyslipidemia is defined as a rise in triglyceride-rich lipoproteins TRLs including chylomicron remnants CMRs and remnant lipoproteins RLPs after eating has drawn an increasing interest recently because of its association with cardiovascular events Chylomicron remnants CMRs have been shown to penetrate the artery wall and to be retained within the intima
Endothelial dysfunction is an initial process of atherogenesis and it contributes to the pathogenesis of CHD Postprandial hyperlipidemia postprandial hypertriglyceridemia is involved in the production of proinflammatory cytokines recruitment of neutrophils and generation of oxidative stress resulting in endothelial dysfunction
Detailed Description:
Coronary artery disease CAD is usually used to refer to the pathological problem affecting the coronary arteries usually atherosclerosis that leads to Coronary Heart disease CHD which includes the diagnoses of angina pectoris MI and silent myocardial ischemia
Despite the mortality for this condition has gradually declined over the last decades in western countries it still causes about one-third of all deaths in people older than 35 years
Dyslipidemia is very important risk factors of atherosclerosis that is one of the causes leading to cardiovascular disease
Despite management of dyslipidemia by controling fasting total plasma cholesterol and LDL cholesterol as these are the best biomarkers for prediction of cardiovascular diseases CVD risk 5LDL elevation is absent in many patients with atherosclerosis and about 13 of cardiac events remains to be unpredicted using this method Even more in fasting normolipidemic subjects increased CVD risk is associated with an exaggerated postprandial lipemic response
Atherosclerosis is initiated by vascular endothelium dysfunction followed by formation of macrophage foam cells which is generated by scavenging of lipids from plasma lipoproteins Accumulation of foam cells and then proliferation of vascular smooth muscle cells VSMCs causes the appearance of fatty streaks the first visible lesions in the vessel wall
Postprandial dyslipidemia is defined as a rise in triglyceride-rich lipoproteins TRLs including chylomicron remnants CMRs and remnant lipoproteins RLPs after eating has drawn an increasing interest recently because of its association with cardiovascular events Chylomicron remnants CMRs have been shown to penetrate the artery wall and to be retained within the intima
remnant-like lipoproteins RLPs have been found in human atherosclerotic plaque as well910 CMRs and TRLs have also been demonstrated to cause endothelial dysfunction macrophage foam cell formation and the proliferation of VSMCs
Endothelial dysfunction is an initial process of atherogenesis and it contributes to the pathogenesis of CHD Postprandial hyperlipidemia postprandial hypertriglyceridemia is involved in the production of proinflammatory cytokines recruitment of neutrophils and generation of oxidative stress resulting in endothelial dysfunction in healthy subjects hypertriglyceridemic patients
Despite the mortality for this condition has gradually declined over the last decades in western countries it still causes about one-third of all deaths in people older than 35 years
Dyslipidemia is very important risk factors of atherosclerosis that is one of the causes leading to cardiovascular disease
Despite management of dyslipidemia by controling fasting total plasma cholesterol and LDL cholesterol as these are the best biomarkers for prediction of cardiovascular diseases CVD risk 5LDL elevation is absent in many patients with atherosclerosis and about 13 of cardiac events remains to be unpredicted using this method Even more in fasting normolipidemic subjects increased CVD risk is associated with an exaggerated postprandial lipemic response
Atherosclerosis is initiated by vascular endothelium dysfunction followed by formation of macrophage foam cells which is generated by scavenging of lipids from plasma lipoproteins Accumulation of foam cells and then proliferation of vascular smooth muscle cells VSMCs causes the appearance of fatty streaks the first visible lesions in the vessel wall
Postprandial dyslipidemia is defined as a rise in triglyceride-rich lipoproteins TRLs including chylomicron remnants CMRs and remnant lipoproteins RLPs after eating has drawn an increasing interest recently because of its association with cardiovascular events Chylomicron remnants CMRs have been shown to penetrate the artery wall and to be retained within the intima
remnant-like lipoproteins RLPs have been found in human atherosclerotic plaque as well910 CMRs and TRLs have also been demonstrated to cause endothelial dysfunction macrophage foam cell formation and the proliferation of VSMCs
Endothelial dysfunction is an initial process of atherogenesis and it contributes to the pathogenesis of CHD Postprandial hyperlipidemia postprandial hypertriglyceridemia is involved in the production of proinflammatory cytokines recruitment of neutrophils and generation of oxidative stress resulting in endothelial dysfunction in healthy subjects hypertriglyceridemic patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None