Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001928
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Intravenous Levodopa for the Diagnosis of Parkinsons Disease
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Intravenous Levodopa in Parkinsonism
Status:
COMPLETED
Status Verified Date:
1999-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with Parkinsons disease have low levels of the neurotransmitter dopamine Dopamine is responsible for motor function and normal physical activity Patients with Parkinsons disease typically suffer from tremors rigid muscles stooped postures and walk with a shuffle The drug levodopa acts as a replacement for dopamine and has been has been used effectively for over 30 years as treatment for Parkinsons disease Because of its effectiveness levodopa has been used to distinguish Parkinsons disease from other conditions that may resemble Parkinsons disease
Traditionally levodopa has been given as a pill In this study researchers would like to inject levodopa directly into a vein intravenous in order to diagnose cases of Parkinsons disease This method provides immediate results and allows doctors to adjust the dose of levodopa very carefully Because the intravenous method of giving levodopa is less practical than oral medication it is not an available alternative for the routine treatment of Parkinsons disease However it may be useful for faster diagnosis of the disease and for determining effective doses of oral medication
Traditionally levodopa has been given as a pill In this study researchers would like to inject levodopa directly into a vein intravenous in order to diagnose cases of Parkinsons disease This method provides immediate results and allows doctors to adjust the dose of levodopa very carefully Because the intravenous method of giving levodopa is less practical than oral medication it is not an available alternative for the routine treatment of Parkinsons disease However it may be useful for faster diagnosis of the disease and for determining effective doses of oral medication
Detailed Description:
A positive response to levodopa is now considered a condition sine qua non for the diagnosis of idiopathic Parkinsons disease Under this protocol patients with parkinsonism of uncertain etiology will be tested for their motor response to intravenous levodopa to aid in the diagnosis of Parkinsons disease This protocol regulates and stipulates the acute administration of intravenous levodopa and associated safety issues
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-N-0072 | None | None | None |