Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001752
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Vascular and Metabolic Effects of Hormone Therapy Combined With L-Arginine in Postmenopausal Women
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Vascular and Metabolic Effects of Hormone Therapy Combined With L-Arginine in Postmenopausal Women
Status:
COMPLETED
Status Verified Date:
1999-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Estrogen therapy has been associated with reduced risk of coronary heart disease events in observational studies of postmenopausal women Although favorable effects of estrogen on lipoprotein cholesterol levels probably account for much of this benefit direct vascular effects vasomotor hemostatic anti-inflammatory regulated by nitric oxide NO may also be of importance We have recently shown that vasodilator effects of estrogen in the coronary circulation are due to enhanced bioactivity of NO released from the endothelium Estrogen has been shown to stimulate synthesis and activity of the enzyme NO synthase with enhanced NO synthesis in endothelial cells in culture Because L-arginine is the natural substrate for the enzyme NO synthase we propose that the combination of L-arginine and estrogen might have additive vasomotor hemostatic and anti-inflammatory effects in hypercholesterolemic postmenopausal women
Detailed Description:
Estrogen therapy has been associated with reduced risk of coronary heart disease events in observational studies of postmenopausal women Although favorable effects of estrogen on lipoprotein cholesterol levels probably account for much of this benefit direct vascular effects vasomotor hemostatic anti-inflammatory regulated by nitric oxide NO may also be of importance We have recently shown that vasodilator effects of estrogen in the coronary circulation are due to enhanced bioactivity of NO released from the endothelium Estrogen has been shown to stimulate synthesis and activity of the enzyme NO synthase with enhanced NO synthesis in endothelial cells in culture Because L-arginine is the natural substrate for the enzyme NO synthase we propose that the combination of L-arginine and estrogen might have additive vasomotor hemostatic and anti-inflammatory effects in hypercholesterolemic postmenopausal women
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-H-0158 | None | None | None |