Ignite Creation Date:
2024-05-05 @ 12:11 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00267891
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2005-12-21
Brief Title:
Brain Changes in Adolescents While Imagining and Observing Aggressive Behavior
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Changes in Activation Patterns in the Ventro-Medial Prefrontal Cortex of Healthy Adolescents During the Imagination and Observation of Aggressive Behavior
Status:
COMPLETED
Status Verified Date:
2010-08-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use functional magnetic resonance imaging fMRI to examine what happens in the brains of adolescents when they are exposed to violent media and how imagining aggressive behavior affects brain function The study will measure physiological changes such as the amount of electricity generated by the skin heart rate and breathing rate related to these tasks during fMRI MRI uses a magnetic field and radio waves to obtain images of body organs and tissues For fMRI the subject performs certain tasks during the MRI scanning to examine changes in the brain regions that are involved with those tasks During the scan the subject lies in a metal cylinder the scanner wearing earplugs to muffle loud noises that occur with the scanning
Healthy right-handed native English-speaking males between 14 and 17 years of age may be eligible for this study Candidates are screened with a neurological examination and neuropsychological testing that includes questions about their feelings experiences and behavior and tests of reading level and intelligence
Participants undergo fMRI and fill out questionnaires before and after the scanning Some children are asked to play 20 minutes of video games before the test During the scan the child views short neutral video clips and video clips of people fighting or imagine self-defense situations The child is asked to rate the video clips for their aggressive content or tell how he or she feels about the imagined situations Two small straps are wrapped around the childs index and middle fingers to measure changes in the amount of electricity generated by the skin and a strap at the ring finger measures the childs heart rate A band around the childs chest records breathing rates
Children who cannot or do not want to undergo MRI testing may be asked to view commercially available video clips of people fighting and neutral video scenes such as sports scenes They are asked to rate them on their violent content and excitement or to rate the video games they have played on their violentnonviolent content and their popularity In addition the children fill out questionnaires about their media use and exposure to violence
All participating families are contacted by telephone 1 day and 2 weeks after the experiment for parents to answer questions about how the child has been doing and for the children to answer questions about their feelings
Healthy right-handed native English-speaking males between 14 and 17 years of age may be eligible for this study Candidates are screened with a neurological examination and neuropsychological testing that includes questions about their feelings experiences and behavior and tests of reading level and intelligence
Participants undergo fMRI and fill out questionnaires before and after the scanning Some children are asked to play 20 minutes of video games before the test During the scan the child views short neutral video clips and video clips of people fighting or imagine self-defense situations The child is asked to rate the video clips for their aggressive content or tell how he or she feels about the imagined situations Two small straps are wrapped around the childs index and middle fingers to measure changes in the amount of electricity generated by the skin and a strap at the ring finger measures the childs heart rate A band around the childs chest records breathing rates
Children who cannot or do not want to undergo MRI testing may be asked to view commercially available video clips of people fighting and neutral video scenes such as sports scenes They are asked to rate them on their violent content and excitement or to rate the video games they have played on their violentnonviolent content and their popularity In addition the children fill out questionnaires about their media use and exposure to violence
All participating families are contacted by telephone 1 day and 2 weeks after the experiment for parents to answer questions about how the child has been doing and for the children to answer questions about their feelings
Detailed Description:
Objective The purpose of the protocol is to localize the prefrontal cortical regions mediating aggressive behavior Utilizing two different experimental neuropsychological tasks during functional MRI we will investigate hypotheses regarding the role of the ventro-medial prefrontal cortex in processing imagined and observed aggressive behavior Additionally we will determine the relationship between non-frontal neural structures involved in emotional expression such as the amygdala and the prefrontal structures involved in executive functions that may modulate aggressive behavior We will record skin conductance responses SCRs heart rates and respiration during the experiments to investigate autonomic changes during the processing of aggressive behavior
Study Population In three separate studies normal adolescent volunteers will participate in experiments dealing with processing of aggressive behavior using functional magnetic resonance imaging fMRI In addition we will conduct two pre-studies in normal adolescent volunteers in order to determine appropriate stimuli for the fMRI studies
Design The experiments we are conducting will employ within-subject rapid event-related fMRI designs to determine whether the observation and imagination of aggressive behavior deactivates the ventro-medial prefrontal cortex VM-PFC and how varying intensities of imagined and observed aggressive acts may influence changes in activation patterns in the VM-PFC
Outcome Measures The data collected will consist of fMRI activation images corresponding to varying intensities of observed or imagined aggression questionnaire results amplitudes of the skin conductance responses heart rates and respiration parameters The results gained from this protocol will provide further evidence for the role of the ventro-medial prefrontal cortex in processing aggressive behavior particularly in adolescents
Study Population In three separate studies normal adolescent volunteers will participate in experiments dealing with processing of aggressive behavior using functional magnetic resonance imaging fMRI In addition we will conduct two pre-studies in normal adolescent volunteers in order to determine appropriate stimuli for the fMRI studies
Design The experiments we are conducting will employ within-subject rapid event-related fMRI designs to determine whether the observation and imagination of aggressive behavior deactivates the ventro-medial prefrontal cortex VM-PFC and how varying intensities of imagined and observed aggressive acts may influence changes in activation patterns in the VM-PFC
Outcome Measures The data collected will consist of fMRI activation images corresponding to varying intensities of observed or imagined aggression questionnaire results amplitudes of the skin conductance responses heart rates and respiration parameters The results gained from this protocol will provide further evidence for the role of the ventro-medial prefrontal cortex in processing aggressive behavior particularly in adolescents
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 06-N-0048 | None | None | None |