Ignite Creation Date:
2024-05-05 @ 12:11 PM
Last Modification Date:
2024-10-26 @ 9:21 AM
Study NCT ID:
NCT00263796
Status:
COMPLETED
Last Update Posted:
2014-04-30
First Post:
2005-12-07
Brief Title:
An fMRI Study of the Effect of Intravenous Oxytocin vs Placebo on Response Inhibition and Face Processing in Autism
Sponsor:
Anagnostou Evdokia MD
Organization:
Anagnostou Evdokia MD
Study Overview
Official Title:
An fMRI Study of the Effect of Intravenous Oxytocin vs Placebo on Response Inhibition and Face Processing in Autism
Status:
COMPLETED
Status Verified Date:
2014-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study the effect of oxytocin on face processing and response inhibition in autistic adults by fMRI
Detailed Description:
Autism is a developmental disorder affecting approximately 6010000 individuals It is characterized by social and language deficits and repetitive behaviorsrestricted interests Functional imaging is becoming a very useful tool in trying to understand the neurobiology of autism Oxytocin is a hormone produced by the brain to assist with labor and lactation Recent evidence suggests that it may be involved in social attachment and in repetitive behaviors In this project we will study how oxytocin changes the way the brain of autistic adults processes faces and deals with response inhibition the ability to interrupt ongoing responses should they prove ineffective or interfering with attaining a goal There is currently no functional imaging data assessing the effect of oxytocin on the brain We will explore the activation patterns in response to oxytocin across circuits involved in social cognition face fusiform area and response inhibition caudate orbitofrontal and dorsolateral cortex by administering a specific fMRI task activating those circuits before and during an oxytocin infusion We will also explore the effect of oxytocin in these areas by administering specific cognitive testing not associated with fMRI before and during oxytocin infusion
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None